ID W5MV80_LEPOC Unreviewed; 1224 AA.
AC W5MV80;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSLOCP00000012289.1};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSLOCP00000012289.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012289.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000012289.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AHAT01001203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01001212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015200287.1; XM_015344801.1.
DR AlphaFoldDB; W5MV80; -.
DR STRING; 7918.ENSLOCP00000012289; -.
DR Ensembl; ENSLOCT00000012310.1; ENSLOCP00000012289.1; ENSLOCG00000010037.1.
DR GeneID; 102692398; -.
DR KEGG; loc:102692398; -.
DR CTD; 132884; -.
DR eggNOG; ENOG502QQ5U; Eukaryota.
DR GeneTree; ENSGT00940000154127; -.
DR HOGENOM; CLU_007621_0_0_1; -.
DR InParanoid; W5MV80; -.
DR OMA; IFFAQIK; -.
DR OrthoDB; 4261679at2759; -.
DR Proteomes; UP000018468; Linkage group LG4.
DR Bgee; ENSLOCG00000010037; Expressed in testis and 11 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0098797; C:plasma membrane protein complex; IBA:GO_Central.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1224
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004866613"
FT TRANSMEM 275..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT COILED 422..461
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 613..640
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 782..809
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1224 AA; 138957 MW; FF4E1EA77A79564E CRC64;
MLFRAITAVL CIVTVQKAMC KEKWATQSCL FSSEKVLNAG ASLYTQSVHR RWPNCSKEPE
DHVIWSCAER GRGTLCRKLG ETPEYCPDPS IASSAPSDPW SHSLFSLISS FKDGVLYWIR
RESSPRHKKI RSLVKAHTFG LTFHKCAQVD VGKEFPTLTI ILLVNNTAGA SAYNLSQLSI
RDAVAGLTLL ANGGNLLESG FQTFTTDSLT AGSCYTVKYS AQMKGEQNDI LSLPAYLTFS
NASQNDINLF GPVVANFTLR VNSTAKVSSN HGIHFVGFLV GFLVASILMT LAFLLFSWIG
IPQMSCCKRK RRGGLSGDTD PEYAVCNVSE TAKEEAAFED KIVDIMILED PQNMYQALEN
LDMSTLLRAA ASLESFRVQV YKDLVAMLLR NLKMNGGVSA LAEKRLNSVL NGQLMGMEGK
LKEEHVARMA ALAAECNRET REEMEAEHRR VTVEKAQAEH LFQQADQQVV LELSVLLDKL
HKLDQSYLQR CLLVRHEEAS AKVQRQTVVC RRLELHKIFF EELEEATRMK ELEKNVANQL
LHAYFSSQDQ LEEVLDIFLA NQRSILEERH AQRQFLAHSL QSLKTLICEV FTNTSRQMEN
WFQDLKNERY VTEEQANLLL DKAKKELLHV KQNLDEGLNR EKNALHCSLI KKRRSLISDK
LQKHKEEHKD LSAFSRTSEE SLDLADYLSC WQNLLTSQCL ELGDLINNLD EEAAADIRKV
TIRLIQSAMS DIKAIQPNIA QHLMDLGAPR YALLHSGLTH ELVSSALSEA QERLHKEGKI
AVKTLQRSRD TLQEQLRLEL QEQQTLRQRG RAVFQNLCRA QLTMSDDDLL KMKLEFQYCL
SRMDKCLVLP RALARSRLQV CLSDWRKTML MKMEHNYAAL QEKQVLAELQ HEREDLLKSQ
EERLGAHITA LQFQKAEKRA KALETYAAIL NLQSLLVEEL SISGSMTTPE IAQTIQNHSH
GLEVTENLLQ KCLADWKALT VAPTLTSGPD APSAEISKEE EDCRMTVRLQ QALNKSHHVM
HLQRNRLKEE HTRYQIKEDL KEQLEFKTLH IHFDQDLEFA ASLVKQSQIS ACVLLEVLHL
FLPTSSESEL ISIIDVLLPK PPSNEREKGW TDGSRKSLLI KLREDIISKN VISGPLDKGF
ERVLMKKQVD VETSRSVRNS VVQNIIEDQC SDPAAEILDL HDTGEKVFVF RFESEQKDFS
DTICKKKKKR SFLNFKKATV ANID
//