ID W5MVZ1_LEPOC Unreviewed; 260 AA.
AC W5MVZ1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Calbindin {ECO:0000256|ARBA:ARBA00018599};
GN Name=CALB1 {ECO:0000313|Ensembl:ENSLOCP00000012550.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012550.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000012550.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-
CC ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
CC {ECO:0000256|ARBA:ARBA00025400}.
CC -!- SIMILARITY: Belongs to the calbindin family.
CC {ECO:0000256|ARBA:ARBA00007217}.
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DR EMBL; AHAT01004672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01004673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006636064.1; XM_006636001.2.
DR AlphaFoldDB; W5MVZ1; -.
DR Ensembl; ENSLOCT00000012573.1; ENSLOCP00000012550.1; ENSLOCG00000010243.1.
DR GeneID; 102691626; -.
DR KEGG; loc:102691626; -.
DR CTD; 793; -.
DR GeneTree; ENSGT00950000183108; -.
DR HOGENOM; CLU_054826_1_1_1; -.
DR OrthoDB; 3218718at2759; -.
DR Proteomes; UP000018468; Linkage group LG11.
DR Bgee; ENSLOCG00000010243; Expressed in mesonephros and 9 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005499; F:vitamin D binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.238.10; EF-hand; 3.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR19972; CALBINDIN; 1.
DR PANTHER; PTHR19972:SF14; CALBINDIN; 1.
DR Pfam; PF00036; EF-hand_1; 1.
DR Pfam; PF13499; EF-hand_7; 2.
DR SMART; SM00054; EFh; 4.
DR SUPFAM; SSF47473; EF-hand; 2.
DR PROSITE; PS00018; EF_HAND_1; 4.
DR PROSITE; PS50222; EF_HAND_2; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Vitamin D {ECO:0000256|ARBA:ARBA00022897}.
FT DOMAIN 11..46
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 97..132
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 141..176
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 185..220
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 260 AA; 30128 MW; CA1ABCA5E6D2B4A9 CRC64;
MANAYLQGVE ISATQFLDIF RHYDNDGNGY IEGKELQNFI KELQQARKQA GLELTEQMKA
FVEEYEQNAG GKIGIVELVQ ILPTEENFLL FFRQQLKSCA EFMQAWRKYD ADHSGYIEAD
ELKNFLRDLL LKAKKTYDDK KLDEYTQTTL KIFDSNNDGK LCLAEMARLL PDQENFLLKF
QGVKMPRKEF NKIFELYDQD GNGYMDENEL DALLKDLCEK NQKVLDIKNI ATYKKTIMAL
SDGGKLYRTE LALVLCADEN
//
