ID W5MWK0_LEPOC Unreviewed; 657 AA.
AC W5MWK0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Carnitine O-octanoyltransferase {ECO:0000313|Ensembl:ENSLOCP00000012759.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012759.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000012759.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR EMBL; AHAT01004662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01004663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01004664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01004665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MWK0; -.
DR STRING; 7918.ENSLOCP00000012759; -.
DR Ensembl; ENSLOCT00000012783.1; ENSLOCP00000012759.1; ENSLOCG00000010406.1.
DR eggNOG; KOG0817; Eukaryota.
DR eggNOG; KOG3718; Eukaryota.
DR GeneTree; ENSGT01060000248556; -.
DR HOGENOM; CLU_013513_5_3_1; -.
DR InParanoid; W5MWK0; -.
DR Proteomes; UP000018468; Linkage group LG11.
DR Bgee; ENSLOCG00000010406; Expressed in brain and 13 other cell types or tissues.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0008458; F:carnitine O-octanoyltransferase activity; IBA:GO_Central.
DR GO; GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000582; Acyl-CoA-binding_protein.
DR InterPro; IPR035984; Acyl-CoA-binding_sf.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF67; PEROXISOMAL CARNITINE O-OCTANOYLTRANSFERASE; 1.
DR Pfam; PF00887; ACBP; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR PRINTS; PR00689; ACOABINDINGP.
DR SUPFAM; SSF47027; Acyl-CoA binding protein; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS51228; ACB_2; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT DOMAIN 1..96
FT /note="ACB"
FT /evidence="ECO:0000259|PROSITE:PS51228"
FT ACT_SITE 370
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 657 AA; 75662 MW; E28A10603702B525 CRC64;
VFNQADFEKM AEDVKKVKSR PEDKELLELY GLYKQATVGD NHIDKPGLFN PKADAKWEAW
NSRKGRRSIF ASAMAFKMIE FIQLHNFKKL VSSICHRKGL YKRTEEQISW SYELFQQEQF
RRDLLFKSIF QSTSVSQLIL NWSWETKVFF RESLITPPFG VNHHKVLMCN WKAVQYPNNS
KTKRILKNKS SCLTLHVTYL RCLHFNWKHA IFSLTEEIRN LTEEQYMGKV AQHEKVLWKE
RQHTFEVLLC GNHILSPSEV IMQITYIRER CTSQPDGAGV SALTTEERTC WAKAREHLIE
LDPNNGAILE AIQSSLFIVS LDEARPFSTP ENYTEMILQA LTGDPTARWG DKSYNIICFA
DGTFGSNCDH APYDAMVLVS MCYYIDQKLK ASEGRWKGSV AAREIPPPEE LVFTVDQKAQ
ADIALAKQRY RESGRRELRC MWWVVDRAGR VFFLTRTEDF LLQPRFHSNA CKHFGHTSCT
NFIPQNATTR RFYHGRTETM RPCTLEALEW CKAMLDPSVN TETKRKCLLI AVAKHNKLMN
EAQNGKGFDR HLLGLYLIAK GEGLPVPELY QDPAYSKSGG GGNFVLSTSL VGYTTVLGAV
VPMVHHGYGF FYRIRDDRIV VSCTAWKSCP ETDAEKLYQN LTTSFQEMLQ LMTLSQL
//
