ID W5MX21_LEPOC Unreviewed; 240 AA.
AC W5MX21;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Carboxypeptidase B2 (plasma) {ECO:0000313|Ensembl:ENSLOCP00000012930.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000012930.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000012930.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M14 family.
CC {ECO:0000256|ARBA:ARBA00005988}.
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DR EMBL; AHAT01003592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5MX21; -.
DR STRING; 7918.ENSLOCP00000012930; -.
DR Ensembl; ENSLOCT00000012957.1; ENSLOCP00000012930.1; ENSLOCG00000010552.1.
DR eggNOG; KOG2650; Eukaryota.
DR GeneTree; ENSGT00940000159160; -.
DR HOGENOM; CLU_019326_0_2_1; -.
DR InParanoid; W5MX21; -.
DR OMA; WITHSSI; -.
DR Proteomes; UP000018468; Linkage group LG17.
DR Bgee; ENSLOCG00000010552; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR000834; Peptidase_M14.
DR PANTHER; PTHR11705:SF17; CARBOXYPEPTIDASE B2; 1.
DR PANTHER; PTHR11705; PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B; 1.
DR Pfam; PF00246; Peptidase_M14; 1.
DR PRINTS; PR00765; CRBOXYPTASEA.
DR SMART; SM00631; Zn_pept; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS00133; CARBOXYPEPT_ZN_2; 1.
PE 3: Inferred from homology;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022645};
KW Protease {ECO:0000256|ARBA:ARBA00022645};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 217..227
FT /note="Peptidase M14 carboxypeptidase A"
FT /evidence="ECO:0000259|PROSITE:PS00133"
SQ SEQUENCE 240 AA; 28378 MW; E4D66AECAA090793 CRC64;
FRVLLENVQE LIDMQTKNDS NDPRSSVSFY ERYHPLDEIY SWINKTAQDN PHLVRTILIG
STFEKRPLYV LKLSGRNPSR AMWMDCGIHA REWISPAFCL WFVQYVIQFY NTNPEITQIL
DNMDIYILPV LNPDGYLFTW TNNRMWRKNR SQYEDSDCIG ADLNRNFDAN WCTEGSSPRP
CDETYCGPFP ESESETKAVA TFLRSKKHIM KLYISIHSYS QMLLFPYSYT YKQADNHNEL
//
