ID W5MXB5_LEPOC Unreviewed; 486 AA.
AC W5MXB5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Fizzy-related protein homolog {ECO:0000313|Ensembl:ENSLOCP00000013024.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000013024.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000013024.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family.
CC {ECO:0000256|ARBA:ARBA00006445}.
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DR EMBL; AHAT01000185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01000186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006635140.1; XM_006635077.2.
DR RefSeq; XP_015211670.1; XM_015356184.1.
DR RefSeq; XP_015211671.1; XM_015356185.1.
DR AlphaFoldDB; W5MXB5; -.
DR STRING; 7918.ENSLOCP00000013024; -.
DR Ensembl; ENSLOCT00000013052.1; ENSLOCP00000013024.1; ENSLOCG00000010634.1.
DR GeneID; 102692087; -.
DR KEGG; loc:102692087; -.
DR CTD; 100148604; -.
DR eggNOG; KOG0305; Eukaryota.
DR GeneTree; ENSGT00950000183104; -.
DR HOGENOM; CLU_014831_4_2_1; -.
DR InParanoid; W5MXB5; -.
DR OMA; GKHDNRV; -.
DR OrthoDB; 20041at2759; -.
DR Proteomes; UP000018468; Linkage group LG10.
DR Bgee; ENSLOCG00000010634; Expressed in muscle tissue and 13 other cell types or tissues.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IBA:GO_Central.
DR GO; GO:1990757; F:ubiquitin ligase activator activity; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:1905786; P:positive regulation of anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19918; CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED; 1.
DR PANTHER; PTHR19918:SF35; FIZZY-RELATED PROTEIN HOMOLOG ISOFORM X1; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 219..260
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 221..275
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 302..334
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 432..465
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 58..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 53763 MW; 3E39AD1D2ECB4D0D CRC64;
MDQDYERRLL RQINHPNRPE RPLAPSAAVN CTTSVLKSGD RFIPARAGCN WTVNFHSINE
NSKSPNQNRK AKEASSDSGK DAVAYAALLR NELLGASIEK VSDPHTEDRR FTQPAQDTHN
LFRYTVNTKK TPADNGNEVS PYSLSPLSNK SHKLLRSPRK PTRKISKIPF KVLDAPELQD
DFYLNLVDWS AGNVLSVGLG ACVYLWSACT SQVTRLCDLS VDGDSVTSVC WNERGSLVAV
GTHKGYVQIW DAAAGKKLIC LDGHSARVGA LAWNAEQLSS GSRDRLILQR DVRCPAQAER
RLQGHRQEVC GLKWSPDHQH LASGGNDNKL LVWNSSSLVP VQQYTDHLAA VKAIAWSPHQ
HGLLASGGGT ADRCIRFWNT LTGQPLQSTD TGSQVCNLAW SKHANELVST HGYSQNQILV
WKYPSLTQVA KLTGHSYRVL YLAISPDGEA IVTGAGDETL RFWNVFSKTR CTKESKSVLN
LFTRIR
//