ID W5MZL6_LEPOC Unreviewed; 459 AA.
AC W5MZL6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Elongation factor 1-alpha {ECO:0000256|RuleBase:RU000325};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000013825.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000013825.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: This protein promotes the GTP-dependent binding of aminoacyl-
CC tRNA to the A-site of ribosomes during protein biosynthesis.
CC {ECO:0000256|RuleBase:RU000325}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249,
CC ECO:0000256|RuleBase:RU000325}.
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DR EMBL; AHAT01017660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006634422.1; XM_006634359.2.
DR AlphaFoldDB; W5MZL6; -.
DR STRING; 7918.ENSLOCP00000013825; -.
DR Ensembl; ENSLOCT00000013854.1; ENSLOCP00000013825.1; ENSLOCG00000011245.1.
DR GeneID; 102684216; -.
DR KEGG; loc:102684216; -.
DR CTD; 407641; -.
DR eggNOG; KOG0052; Eukaryota.
DR GeneTree; ENSGT00940000165526; -.
DR HOGENOM; CLU_007265_3_5_1; -.
DR InParanoid; W5MZL6; -.
DR OMA; AHVTCRF; -.
DR OrthoDB; 5477300at2759; -.
DR Proteomes; UP000018468; Linkage group LG9.
DR Bgee; ENSLOCG00000011245; Expressed in ovary and 2 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR GO; GO:0006414; P:translational elongation; IBA:GO_Central.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03693; EF1_alpha_II; 1.
DR CDD; cd03705; EF1_alpha_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004539; Transl_elong_EF1A_euk/arc.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR NCBIfam; TIGR00483; EF-1_alpha; 1.
DR PANTHER; PTHR23115:SF191; ELONGATION FACTOR 1-ALPHA; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000256|RuleBase:RU000325};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000325};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000325};
KW Protein biosynthesis {ECO:0000256|RuleBase:RU000325};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 5..240
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 459 AA; 50544 MW; 55FE3C362836D502 CRC64;
MPKDRVHINL VIIGHVDSGK STTTGHLVYK CGGVDPRTIE KFEKTASQMG KGSFKYAWIL
DKLKAERERG ITIDISLMKF NTHKFYITII DAPGHRDFIK NMITGTSQAD AALLVVSAAR
GEFEAGISRN GQTREHALLA YTLGVKQLIV CVNKMDVTEP PYSQKRFDEV VRNVTIYVKK
IGYNPTAVPF VPVSGWAGEN MLTPSNKMPW FKGWKIKRKE GNANGKTLLE VLDSILPPVR
TVNKPLRLPL QDVYKIGGIG TVPVGRIETG ILKPGMMVTF SPARLTAEVK SIEMHHQGLQ
TALPGHNIGF NIKNVSVKNL RRGDVAGNAQ HDPPSDVSSF VAQVIILNHP GKIKAGYSPV
VDCHTAHISC KFAELREKLD RRSGQKLEDD PQVLVSGDAA TVNLVPNKPM CVESFFNYPP
LGRFAARDLR QTIAVGVIKS VEKVNGNPKK SVQKTQSLK
//
