ID W5MZS6_LEPOC Unreviewed; 452 AA.
AC W5MZS6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Interferon regulatory factor 6 {ECO:0000313|Ensembl:ENSLOCP00000013885.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000013885.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000013885.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01016730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006628491.1; XM_006628428.2.
DR AlphaFoldDB; W5MZS6; -.
DR STRING; 7918.ENSLOCP00000013885; -.
DR Ensembl; ENSLOCT00000013914.1; ENSLOCP00000013885.1; ENSLOCG00000011297.1.
DR GeneID; 102682359; -.
DR KEGG; loc:102682359; -.
DR CTD; 3664; -.
DR eggNOG; ENOG502QRNT; Eukaryota.
DR GeneTree; ENSGT00940000157451; -.
DR HOGENOM; CLU_031544_0_1_1; -.
DR InParanoid; W5MZS6; -.
DR OMA; NEAWPKE; -.
DR OrthoDB; 3740806at2759; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000011297; Expressed in zone of skin and 9 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048702; P:embryonic neurocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0008544; P:epidermis development; IEA:Ensembl.
DR GO; GO:0060429; P:epithelium development; IEA:Ensembl.
DR GO; GO:1905748; P:hard palate morphogenesis; IEA:Ensembl.
DR GO; GO:0002376; P:immune system process; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF9; INTERFERON REGULATORY FACTOR 6; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 7..115
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
FT REGION 119..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 51639 MW; CB8238B975D9686E CRC64;
MAAHPRRVRL KPWLVSQVDS GKYPGLVWLD REAKRFQIPW KHATRHSPQH EEENTIFKAW
AVETGKFQEG VDEPDPAKWK AQLRCALNKS REFNLIYDGT KEVPMNPLKI YDVCDIPQPL
SNPGSTGSVP WEENDGEPEE DEEESLEPIP YLQMNGSVSP IQPPSCPPPA PEVWPKEEPT
DFEMRASPLP ETMFTSPEMW ISSLPMTDLE VQFQYRGKEV CPPMTVSNPQ GCRLFYGDLG
PMVNQEELFG PISLEQVRFP STENITNEKQ RLFTNRLLDV MDRGLILEVS GHDIYAVRLC
QCKVYWSGPC ASSPTTPNLI ERQRKVKLFC LETFLSGVIA HQKGQADRPP QFEIHLCFGE
EWPDGRPRER KLIMVQVIPV VARMIYEMFS GDFTRSFDSG SVRLQISTPD IKDNIVTHLK
QLYRLLQTHQ GHEAWLLQPG GSLHLPQALQ AQ
//
