ID W5N1M9_LEPOC Unreviewed; 673 AA.
AC W5N1M9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Homeobox domain-containing protein {ECO:0000259|PROSITE:PS50071};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000014538.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000014538.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family.
CC {ECO:0000256|ARBA:ARBA00006317}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01004514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5N1M9; -.
DR STRING; 7918.ENSLOCP00000014538; -.
DR Ensembl; ENSLOCT00000014567.1; ENSLOCP00000014538.1; ENSLOCG00000011824.1.
DR eggNOG; KOG0487; Eukaryota.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000164628; -.
DR HOGENOM; CLU_408596_0_0_1; -.
DR InParanoid; W5N1M9; -.
DR Proteomes; UP000018468; Linkage group LG11.
DR Bgee; ENSLOCG00000011824; Expressed in intestine and 9 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR006711; Hox9_activation_N.
DR PANTHER; PTHR45970; AGAP004664-PA; 1.
DR PANTHER; PTHR45970:SF3; HOMEOBOX PROTEIN HOX-A9; 1.
DR Pfam; PF00046; Homeodomain; 2.
DR Pfam; PF04617; Hox9_act; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 162..207
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 593..653
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 164..208
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT DNA_BIND 595..654
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 24..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 75692 MW; 9B72575EEE0E6B4F CRC64;
MSASGTLSNY YVDSLIFHES EDLFQPRHPS GSGVQPARQP ALSEHSDLAP CNFQPKPSVF
GASWSPVHAQ QPSNLPSVYH PYVHHQGPPG ESDGGYLRSW LLEPLSGSLP FPGLPSNRQY
GIKHEPLSRR GDCTAIHICH GEGRTTRVLP RDNPASNWLH ARSTRKKRCP YTKHQTLELE
KEFLFNMYLT RDRRYEVARL LNLTERQEMG ILHKTALRFS TNTRRERIHS QQTQQNVDLN
YSFQINTQKL IKNTLGCENR AALIFVLCLG RDIKGNKRVH HRNVFGVTGV YANKSPSKIM
SSSYYVNSIF SKYAAGTSLF QNVDQSSCSF APSVQRSAYG PGTSAFSSAL PGLYTVNNAM
YQNPSVLTSG YNLGSEGYNL HCNSFDQSLP VLCNDLAKGG SDKTGPADLS SHSESSFRMY
PWMRTSVCSC LFSPILEKIC RCPFAPLGNS AQKCTNTQQI TIVRFVAQMS SFFVNPAFPA
SLPAGQDSFL GQIPLYTSGY DALRHFPAPH GAPYEYGPSC YHSDKDPVSV YPAGSDKQGA
GDSCLQFCGD QHCKPDCTQS KIFGNEPPDR KYPASAHPWM QRMNSCNASI YGSHGRRGRQ
TYSRYQTLEL EKEFHFNRYL TRRRRIEIAN ALCLTERQIK IWFQNRRMKW KKENKILSSA
EENSEEVKEK TGE
//
