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Database: UniProt
Entry: W5N255_LEPOC
LinkDB: W5N255_LEPOC
Original site: W5N255_LEPOC 
ID   W5N255_LEPOC            Unreviewed;       890 AA.
AC   W5N255;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   25-APR-2018, entry version 31.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide-gated potassium channel 1 {ECO:0000313|Ensembl:ENSLOCP00000014714};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000014714, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000014714, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000014714}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; AHAT01017239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01017240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006627205.1; XM_006627142.2.
DR   Ensembl; ENSLOCT00000014743; ENSLOCP00000014714; ENSLOCG00000011966.
DR   GeneID; 102687203; -.
DR   CTD; 348980; -.
DR   GeneTree; ENSGT00900000140801; -.
DR   OMA; TRTFHYA; -.
DR   Proteomes; UP000018468; Linkage group LG2.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0030552; F:cAMP binding; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0007270; P:neuron-neuron synaptic transmission; IEA:Ensembl.
DR   GO; GO:0035677; P:posterior lateral line neuromast hair cell development; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR030169; K/Na_HCN1.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF373; PTHR10217:SF373; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Ion channel {ECO:0000256|SAAS:SAAS00084808};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    120    144       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      452    558       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   890 AA;  100369 MW;  035852B15D5A688F CRC64;
     MADKSNSFSS NKEEKSDGNN VFQRQDSIQK NNMGSQNMKD HGNSVGFKMD REEAVVGFED
     LDGSSRQSGF MQRQIGAMLQ PGVNKFSLRM FGSQKAVEKE QERVQTAGYW IIHPYSDFRF
     YWDLIMLIMM VGNLIIIPVG ITFFTEQTTT PWLVFNVASD TIFLVDLVMN FRTGIVNEES
     SEIILDPKVI KMNYLKSWFV VDFLSSIPVD YIFLIVEKGF DSEVYKTARA LRIVRFTKIL
     SLLRLLRLSR LIRYIHQWEE IFHMTYDLAS AVVRIFNLIG MMLLLCHWDG CLQFLVPLLQ
     DFPPDCWVSL NGMVNDSWGK QYSYALFKAM SHMLCIGYGA RAPVSMSDLW ITMLSMIVGA
     TCYAMFVGHA TALIQSLDSS RRQYQEKYKQ VEQYMSFHKL PADMRQKIHD YYEHRYQGKI
     FDEENILSEL NDPLKEEIVN FNCRKLVATM PLFANADPNF VTGMLSKLKF EVFQPNDYII
     REGTVGKKMY FIQHGVASVI TKLNKEMKLT DGSYFGEICL LTKGRRTASV KADTYCRLYS
     LSVDHFNEVL EEYPMMRRAF ETVAIDRLDR IGKKNSLLLQ KFQKDLNAGV FNTQENEILK
     QIIRQDREMV MMVDRKPSVT GMNSTPISGN SIINSPGQLP YTAALSNSQF QQSAPLTYST
     PSTMVPRVLS GPPQPAYAVP SMSHGNLNSS SPSPQTPLQQ QQCAVMSPCS FTTAVCSPPV
     QSPLAGRTFQ YGSPTASQLS LIQQSLPPPP TQQQQQQQQV PSPQRSDIHK STQALHSGSL
     SREVRPLSAS QPSLPHETSL LSRPHPTSGE SLASIPPPVS AVQGTGLQSG IRTTVPQRVT
     LFRQMSSGAL PPVRAPPASQ HRDSLGSRRE STVLSSTETD QDKLRFASNL
//
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