ID W5N2A4_LEPOC Unreviewed; 1377 AA.
AC W5N2A4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Neurofascin homolog (chicken) a {ECO:0000313|Ensembl:ENSLOCP00000014763.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000014763.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000014763.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR EMBL; AHAT01016688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000014763; -.
DR Ensembl; ENSLOCT00000014792.1; ENSLOCP00000014763.1; ENSLOCG00000011984.1.
DR eggNOG; KOG3513; Eukaryota.
DR GeneTree; ENSGT00940000157024; -.
DR InParanoid; W5N2A4; -.
DR OMA; NHSSYPG; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000011984; Expressed in ovary and 11 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098632; F:cell-cell adhesion mediator activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR CDD; cd00063; FN3; 5.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05731; Ig3_L1-CAM_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1377
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004866893"
FT TRANSMEM 1239..1260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..129
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 143..230
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 264..352
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 357..444
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 455..537
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 542..648
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 669..764
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 769..862
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 867..971
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 972..1071
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 652..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 751..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1271..1377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1271..1304
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1305..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1363..1377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1377 AA; 154119 MW; 5E0FD08F385CD1D0 CRC64;
MLTRGRRLSP TGLALLFLWT EVSTIEVPLD PKIQQDLKQP PTIIKQSVKD YIVDPRDNII
IECEAKGNPL PVFSWRRNGR FFNVGKDPRV SMRKRSGTLE IGFRSGGRPE DYEGEYQCLA
TNDYGTALSN KILLRVSKSP LWPKEVLEPV VVNEGSSLIL ACNPPPGLPP PSTFWMNSSM
MPIVQDRRVS MGLNGDLYFS NVLAKDAQTD YSCNARFLFT HTIQQKNPFT LKVLTKEPYN
DTSVFSSLNH TDFYSARGVA ETTPTFLSPT GTSSFKMVLR GQDLLLECIA AGVPTPSIKW
FKKGGDLPAQ KAKFDNFNKT LRISGVSEED SGEYFCMANN KIGSIRHTVS VQVKAAPYWL
DKPSNLVLAP DESGRLVCRA NGSPKPTIQW LVNGEPIQSA PPNPSREVVG DTIIFRSVQI
GSSAVYQCNA SNGHGYLLAN AFVSILDMQP RMLGPKNQLI KVIENNRTFL DCPFFGSPLP
ELRWFKNGQG SNLDGGQYRV YSNGTLEIRR TRPEDQGTYT CVATNILGNA ENQVRLEVKE
STRIVRAPEH LTAVRGTVAR FDCRINYDPS LRLTISWLKD DVPVSLGWRN FIQIIGNWFK
DVVAMFYPRM KKDEDSLAIH NVNEGDEGTY TCTASTELDS DSASARLTVL DDPLSPTNRS
AVVPDRPDPP TDLELSDPSE RSVRLTWIPG DDNHSPITNF LVQFEEDRWE PNKWKNLSIY
PGNLNSVLLQ LSPFINYQFR VIAINAIGAS RPSRPSQRYQ TSGAPPDAIP GQLRGAGTKK
TNMEITWEAL LDTQRNGPNL RYVVWWRRQG SREEWKNITT KWLKHVIYDT DTYTPYDIKI
QAVNDFGPGP ESPVITGYSG EDRPLAAPTN LRVSKIESMR VHLMWNSVPP STVQGEMKEY
KVYYWRESSV LKWLTVNREK KTRSFQGTMS RPSGWLPNLI PYSNYKAYVV MANNRYEGPQ
SNVVDFQTKE GVPSAPKYFR IQQRHMDTIY LDWDKPAEPN GILTGYTLKY QTVNGTRMGR
MVTENFSPNV TSFSMRRPDR YTRYKFQLNA RTQAGAGEVY IEESPHSANE EDFAITVVTP
TPSPADLVPT PTAATPTTSI SATPETTTVT APTAAPTTVV STVAATRPVP DRPVLVAPGR
RIWNLTVEPN SNYANVSWEH NFPPDSTAFV IEFIDSNGTR KSVTVNHQTP VKLAGLTEGA
KYELRVYSRE YETVSSKTVT FETSAAYTKD QVDIATQGWF IGLMCAIALL VLILLIVCFI
KRSRGGKYPV RDKKDLPLDP VDQKDQDGSF DYRNENRSLE SDEDNKPLQG SQTSLDGMVK
MQESDDSLVD YGEGGDGQFN EDGSFIGQYT VKKDKDETEG NESSEATSPV NAIYSLA
//
