ID W5N2M8_LEPOC Unreviewed; 480 AA.
AC W5N2M8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Solute carrier family 39 member 8 {ECO:0000313|Ensembl:ENSLOCP00000014887.1};
GN Name=SLC39A8 {ECO:0000313|Ensembl:ENSLOCP00000014887.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000014887.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000014887.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR EMBL; AHAT01017793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015200709.1; XM_015345223.1.
DR AlphaFoldDB; W5N2M8; -.
DR STRING; 7918.ENSLOCP00000014887; -.
DR Ensembl; ENSLOCT00000014916.1; ENSLOCP00000014887.1; ENSLOCG00000012098.1.
DR GeneID; 102693943; -.
DR KEGG; loc:102693943; -.
DR CTD; 64116; -.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000158926; -.
DR HOGENOM; CLU_015114_13_0_1; -.
DR InParanoid; W5N2M8; -.
DR OMA; ITMFAGE; -.
DR OrthoDB; 5488029at2759; -.
DR Proteomes; UP000018468; Linkage group LG4.
DR Bgee; ENSLOCG00000012098; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140410; F:monoatomic cation:bicarbonate symporter activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071578; P:zinc ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191:SF2; METAL CATION SYMPORTER ZIP8; 1.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 243..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 53032 MW; EA8FEE59A7CD0BF6 CRC64;
MFNTSSYRIV AFIVRTLFLI ATLHILTSKA TVIYKRKSFL EDIFGYYGEN ETFSSGKLES
LLYRVGSRRP QDNVGELEAL HNSQCLSSGD ILSLHELNNQ SRLTMSDFEK ICPAILQQAV
VRPCLLSTQE PEPSVPHKPV SYHVWGYGVL AVTIINMASL LGLILVPFTK KPYFPKLLTY
FTGLAIGTLY SNAVLQLIPE ALGFDPKKDN YVLNAVGIFG GFYVLFFTEK ILQFALKPEH
KQGHSHFNTS EEESNQSNAN KMGTNSVTNG ELTHKTEIIT VTSFSCSEEP SIGTAAQTDQ
DIQVSRGYCR WLSGPRIRNI KTVAWMITLS DALHNFIDGL AIGASFTVSV INGVSTSIAI
VCEEFPHELG DFVILLSAGM SIPQALFFNL LSACSCYIGL ILGIVVGTNF SPNVIFAFAG
GMFLYIALAD MFLEMNNIQG DHERNTRSKI IFFTIQNLGL LTGFSVILLI TMFAGNIKLE
//
