ID W5N3M8_LEPOC Unreviewed; 490 AA.
AC W5N3M8;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Regulator of G protein signaling 6 {ECO:0000313|Ensembl:ENSLOCP00000015237.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015237.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000015237.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01019057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01019058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01019059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01019060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006632496.1; XM_006632433.2.
DR RefSeq; XP_015206234.1; XM_015350748.1.
DR AlphaFoldDB; W5N3M8; -.
DR Ensembl; ENSLOCT00000015266.1; ENSLOCP00000015237.1; ENSLOCG00000012364.1.
DR GeneID; 102687561; -.
DR KEGG; loc:102687561; -.
DR CTD; 9628; -.
DR GeneTree; ENSGT00940000157159; -.
DR HOGENOM; CLU_025092_4_0_1; -.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000018468; Linkage group LG7.
DR Bgee; ENSLOCG00000012364; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF2; REGULATOR OF G-PROTEIN SIGNALING 6; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 40..115
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 336..451
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 56765 MW; 100DB0B6DE4C6BA2 CRC64;
MAQAPKDQAA VGTADPDEDS PNMIVYRKIE DIITQIQDEK AGGVPIRTVK SFLSKIPSVV
TGADIVQWLM KNLNIEDPVE AIHLGSLIAA QGYFFPISDH VLTLKDDGTF YRFQAPYFWP
SHCWEPENTD YAIYLCKRTM QNKARLELAD YEAENLARLQ RAFARKWEFI FMQAEAQVKV
DRKKDKTERK ILDSQERAFW DVHRPVPGCV NTTEMDIRKC RRMKNPQKVK KSVYGVTEES
QTRSPVHTPA QPVRKTTKED VRKEITFLNM QLDRHCMKMS KVAESLMTYT EQFLEYDPFV
SMPEPSNPWI SDDTTFWDLE ASKEPSQQRV KRWGFSLDEA LKDPVGRDLF LKFLESEFSS
ENLRFWLAVQ DLKRHPLQDV PARAQEIWQE FLAAGAPSAI NLDSHSYERT SQNIKDPGRY
SFEDAQEHIY KLMKSDSYAR FLRSNTYQDL LLAKKKPENE QGRRTSLEKF TRSVGKSLTG
KRLTGLMQSS
//
