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Database: UniProt
Entry: W5N3V9_LEPOC
LinkDB: W5N3V9_LEPOC
Original site: W5N3V9_LEPOC 
ID   W5N3V9_LEPOC            Unreviewed;      2667 AA.
AC   W5N3V9;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   16-JAN-2019, entry version 28.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 3 {ECO:0000313|Ensembl:ENSLOCP00000015318};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015318, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Ensembl:ENSLOCP00000015318, ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000015318}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
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DR   EMBL; AHAT01016614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSLOCT00000015347; ENSLOCP00000015318; ENSLOCG00000012422.
DR   GeneTree; ENSGT00940000157078; -.
DR   OMA; SFYNLMT; -.
DR   Proteomes; UP000018468; Linkage group LG3.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018468};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2187   2211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2223   2243       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2255   2282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2302   2330       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2351   2373       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2478   2501       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      113    173       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      174    224       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    288       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      295    370       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      376    432       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       89    110       {ECO:0000256|SAM:Coils}.
FT   COILED      496    516       {ECO:0000256|SAM:Coils}.
FT   COILED     1584   1604       {ECO:0000256|SAM:Coils}.
FT   COILED     1860   1880       {ECO:0000256|SAM:Coils}.
FT   COILED     2616   2636       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2667 AA;  304850 MW;  49C91D7800901C42 CRC64;
     MSEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP VAGDLDNPPK KFRDCLFKVY
     PMNRYSAQKQ FWKAKQAKHE KDKIADVVLL QKLQHAANLE QKQNETENRK VLGEVVKYGS
     VIQLLHMKSN KYLTVNKRLP ALLEKNAMRV TLDSTGNEGS WLFIQPFWKL RANGDNVVVG
     DKVILNPANA GQPLHASNYE LSDHPGSKEV NSVNCNTSWK INLFMMFSDH KDEVLKGGDV
     VRLFHAEQEK FLTCDEYKGK LHVFLRTTLR QSATSATSSN ALWEVEVVHH DPCRGGAGHW
     NSLYRFKHLA TGNYLAAEEN PSYKGDNGET RSVVNTGRSS KRNMGEKVKY KLVAVPHGND
     IASLFELDPT TLQKTDSFVP RNSYVRLRHL CTNTWIQSTN VPIDIDEERP IRLMLGTCPT
     KEDKEAFAIV SVPVSEIRDL DFANDASFML ATVVDKLNEG FISQNDRRFA IKLLEDLVFF
     VVDTPNTGQS VLDVVITKAN RERQKLMREQ NILKQIFGIL KAPFKDKGAE GPLLRLEELA
     DQKNAPYQYM FRLCYRVLRH SQEEYRKNQE HIAKQFGVMQ SQIGYDILAE DTITALLHNN
     RKLLEKHITK TEVETFVSLV RKNREPRFLD YLSDLCVSNH VAIPVTQELI CKCVLDPKNQ
     DILIKTERRV PKEMPQTTEY SISLEEYGDE DEVWLVWTDK NNEKQEKSIR QLAQEARQGN
     AHDENVLTYY RYQLKLFARM CLDRQYLAID EISKQLDVEL IFLCMMDEAL PYDLRASFCR
     LMLHTHVDRD PQELVTPVKF ARLWTEIPTS ITIKDYDSNM DDSRDNKKNK FANTMAFMEE
     YLNNVLNDDL PFSNDEKNKL TYEVVSLARH LIYFGFYSFF ELLRLTRTLL GIIDCIPNPA
     LMHNMFQDDV AGKNLKRSIH GVGHMMTTMV LSRKQSIFGG PGRSSVSVDP QARSKDSIDK
     QDVTVMDTKL KILEIMQFIL NVRLDYRISF LLSVFKKEFV EVYPMEDADA TAAIEHAAAT
     INLQRIGEQA EAMFGVGKNN SILEVDDEGG RMFLRVLIHL TMHDYPPLIS GALQLLFKHF
     SQRQEVLHTF KQVQLLISAQ DVDNYKLIKS DLDRLRTMVE KSELWVDKKS SSAGGGEGKM
     DKKEKEAVPE APEPKKEKSE KSNENYQIVK QILERLNKMC SSGVWKKQQR LLKNMGAHKV
     MLDLLQVSYD KSDMKMQEII KYTHQFLQKF CMGNPENQAL LHKNLSLFLN PGLLEAETVQ
     YIFANNYQLC SEISETVLQH FIHCLATHGR HVQYLNFLHT IIKAEGKYVK KCQDMIMTEL
     TNAGEDVVVF YNDKTSFAIM LELMAESREG VQENSPLRYH ISLVELLAAC AEGKNVYTEI
     KCTSLLPLED VVRVVTHEDC ITEVKIAYVN FVNHCYVDTE VEMKEIYTSN HIWKMFENFT
     VDMARVCNKR EKRFQDPTLE RYVITVVLDT INAFFSSPFS ENSTALQTHQ TIVIQLLQST
     VRLLDCPWLQ QQHRALVEAC IRTLAMTAKG RSIVLPVELD TQISTMLSSS VLGSLSRNNP
     NYKSLTRSNR PPAPNNPWDY KNIIEKLQDI INTLEERLKP LVEAELSVLV DVLHHPELLF
     IEGTEARSRC ETGGFISKLI QHTKTLMTSE EKLCIKVLRT LQEMLIRKYD FDEKSISLRK
     VLLQNYLYNK KSGGRGELPE LTLGGLEVDR DWATVAAVQC RLDREGGTKL VTDLIMSSKN
     DKIFFESIQL AISLLEGGNT EIQNSFYKLM MGDNKSEKFF KVLHDRMRSA QQDIKATVSV
     NVGEMSNKAR DSKEMDSSGP AHFAMADSTG KLHAGRAAVS EQPETEAEMG PAVMIMKPIL
     RFLQLLCENH NQDLQNFLRN QNNKTNYNLV CETLQFLDIM CGSTTGGLGL LGLYINENNV
     GLITQTLETL TEYCQGPCQE NQTCIVTHES NGIDIITALI LNDISPLCRY RMEMVLQLKD
     NASKLLLALM ESRHDNENAE RILFNLRPQE LVEVIKKAYH QEDECEGGEV SPREVGHNIY
     ILALQLARHN KNLIHLLKPL KRTQEEDEEG ISSMLNLNNR QLSKMLKSSA PEGEKKEDPL
     EYYEQHTAQI EIVREDRSME QIVFPVHSIC EFLMEESKHR VFTTTEQDEQ GSKVSDFFEQ
     TSFLHNEMEW QKKLRSMPVL YWFSRRMTLW GSISFNLAVF INLLIAVFYP YSTEPVESPI
     VPMLFWVMAG LSVMGLFSQR YGLRPLTVAL ILRSIYYLGI GPTLILLGTL NLINKIVFVV
     SFVGNRGTFI RGYKAMIMDM EFLYHVGYVL TSTLGLCVHE LFYSILLFDL IYREETLFNV
     IKSVTRNGRS ILLTALLALI LVYLFSIVGF LFLKNDFIME VDHLSQAKDT DIASGYGEAA
     KDFLNSCSGD GVSCTTEDNT PAVPEEEDDG TERACDTLLM CIVTVLNHGL RNGGGVGDVL
     RKPSKDEALF PARVVYDLLF YFIVIIIVLN LIFGVIIDTF ADLRSEKQKK EEILKTTCFI
     CGLERDKFDN KTVSFEEHIK IEHNIWNYLY FIVLVREKNK TDYTGPESYV AMMIKNKNLD
     WFPRMQAMSL VVTDTDGEQN EMRNLQDKLN STMKLVTHLT TQLTELKEQM TEQRKRRQRM
     GFVDVQGSSS ATPTGAGAGG NHQIVKT
//
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