ID W5N462_LEPOC Unreviewed; 156 AA.
AC W5N462;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Cyclin dependent kinase inhibitor 1A {ECO:0000313|Ensembl:ENSLOCP00000015421.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015421.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000015421.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CDI family. {ECO:0000256|ARBA:ARBA00006726}.
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DR EMBL; AHAT01016599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006628655.2; XM_006628592.2.
DR AlphaFoldDB; W5N462; -.
DR STRING; 7918.ENSLOCP00000015421; -.
DR Ensembl; ENSLOCT00000015450.1; ENSLOCP00000015421.1; ENSLOCG00000012523.1.
DR GeneID; 102697870; -.
DR KEGG; loc:102697870; -.
DR CTD; 1026; -.
DR eggNOG; KOG4743; Eukaryota.
DR GeneTree; ENSGT00940000159918; -.
DR HOGENOM; CLU_077692_1_1_1; -.
DR InParanoid; W5N462; -.
DR OMA; NFAWERV; -.
DR OrthoDB; 692679at2759; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000012523; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IEA:InterPro.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IBA:GO_Central.
DR GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IBA:GO_Central.
DR GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0010165; P:response to X-ray; IEA:Ensembl.
DR GO; GO:0072331; P:signal transduction by p53 class mediator; IEA:InterPro.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IEA:Ensembl.
DR Gene3D; 4.10.365.10; p27; 1.
DR InterPro; IPR003175; CDI_dom.
DR InterPro; IPR044898; CDI_dom_sf.
DR InterPro; IPR029841; CDKN1A.
DR PANTHER; PTHR46778:SF1; CYCLIN-DEPENDENT KINASE INHIBITOR 1; 1.
DR PANTHER; PTHR46778; CYCLIN-DEPENDENT KINASE INHIBITOR 1-RELATED; 1.
DR Pfam; PF02234; CDI; 1.
PE 3: Inferred from homology;
KW Protein kinase inhibitor {ECO:0000256|ARBA:ARBA00023013};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 25..74
FT /note="Cyclin-dependent kinase inhibitor"
FT /evidence="ECO:0000259|Pfam:PF02234"
FT REGION 90..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 156 AA; 17305 MW; EA061C18B7BA3D71 CRC64;
MCGTVAMEKR ALNPLGNAGA AVCRSLFGPV DREELQAEYR ALLRRDLEAS ARRWGFDFLN
ERPLAGGDFE WEGVPGAKVP ALYRTCMVGQ QRGAPQGEQG GKENEARTPE RTAKPRCPES
TPEKSPAQTL KRKQTNITDF YQAKRRLVAT PRKSGQ
//
