ID W5N4J6_LEPOC Unreviewed; 946 AA.
AC W5N4J6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Leukemia inhibitory factor receptor-like {ECO:0000313|Ensembl:ENSLOCP00000015555.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015555.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000015555.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; AHAT01024772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01024773; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015195852.1; XM_015340366.1.
DR RefSeq; XP_015195853.1; XM_015340367.1.
DR RefSeq; XP_015195854.1; XM_015340368.1.
DR AlphaFoldDB; W5N4J6; -.
DR Ensembl; ENSLOCT00000015584.1; ENSLOCP00000015555.1; ENSLOCG00000012627.1.
DR GeneID; 102682152; -.
DR KEGG; loc:102682152; -.
DR CTD; 541493; -.
DR GeneTree; ENSGT00940000165259; -.
DR HOGENOM; CLU_283805_0_0_1; -.
DR OrthoDB; 5347052at2759; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000012627; Expressed in zone of skin and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR048497; LIF-R-like_Ig-like.
DR InterPro; IPR040817; LIFR_D2.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF95; ONCOSTATIN-M-SPECIFIC RECEPTOR SUBUNIT BETA; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF21177; LIF-R_Ig-like; 1.
DR Pfam; PF17971; LIFR_D2; 1.
DR SMART; SM00060; FN3; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..946
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869273"
FT TRANSMEM 715..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 323..419
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 421..518
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 617..715
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 844..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 946 AA; 105295 MW; F4802B0B0FCC825B CRC64;
MQTPLCFLNG LWWFLLSAVL VRESVCEEDL SLPVPQGVTV KPDYQSDILS VEWEDDSSFR
SSSEQYEIEV LLTEKMEVVH RDVYKVLLNN TNKNQWMWIS PMPLNCTSHS LRIRSIHNHK
KSKWSSLVTI QGSDTKDVDE TAVFPIDRVV AVGTNLTFCC VAGKKDNVTD LSFQGKLGTT
YLSNRTLAAQ KKLPLPSISS GDNVICISPS SIGGTVVFVG YAPRDSDLVC ETRDLASVEC
YWNTGNSTYL YGPRRTIYSL TERLSGEGNC SEANVIHGQK YCCKHVVSPG QQQYVFTLRA
VNPLGAVELS DSLDLHHRVY PHNPRYLEVK SVYSRSARLV WDWPKNYDRL SFVCQVEMYS
QDHAEVRNYT LDKKSSWNLE MSHLLPGEKY SVRVRCGVAE DFWKWGDWSH IKQFQTLEES
PVKALDIWRN IIKEEDGQKV VIAWKPLSKR ESNGKIRQYE VTWKSLTDGS EQSFTLPPSD
TSAELNLSNR DYVISVRASN SAGSSPPSIL IVPELLLVNN SVPSVVCAAN GGFHLSWSPN
ASVDCGYIVD WCPTHRLQNC SLYWVKVPLG STNAVIKSED FKPGVQYSFS IYGCTKNRPY
LLERKIGYGQ ELVPSEPVKN LKAEPRSANE VLLQWEDIPL EKKHGFIKGF IIYASNKTGR
SIIAANITNP DARSYVLKRL HSSVYNFTVK AYTAAGEDDG GATVSVFMPG PTDGLIAIIL
ISLGVMAVSS IILTVVCYKK RNWVMQTFYP DIPKPEIRGE QWIPGEGSFV NPPMNVDACD
TSHVCVVGDV LVEQKESDTE EPVVDDNDTG CSSQTILNYY GQVYNGGAGT SSLESNSTEV
TYTNIQPSSS ASASSGYQPQ MTRGPDPEEL GPPLAMPLIC DPAGYQPQAN PKDWTVESPG
PASLNSSLGS PTSINSTQFL LPDQGPEDSQ EPQFSTWFHN FLSMKR
//
