ID W5N4L7_LEPOC Unreviewed; 2047 AA.
AC W5N4L7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Myosin X {ECO:0000313|Ensembl:ENSLOCP00000015576.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015576.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000015576.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AHAT01002485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01002486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000015576; -.
DR Ensembl; ENSLOCT00000015605.1; ENSLOCP00000015576.1; ENSLOCG00000012650.1.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000155469; -.
DR HOGENOM; CLU_001626_1_0_1; -.
DR InParanoid; W5N4L7; -.
DR OMA; HYDVRGI; -.
DR Proteomes; UP000018468; Linkage group LG9.
DR Bgee; ENSLOCG00000012650; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030175; C:filopodium; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IBA:GO_Central.
DR GO; GO:0060002; F:plus-end directed microfilament motor activity; IBA:GO_Central.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR GO; GO:0008360; P:regulation of cell shape; IBA:GO_Central.
DR GO; GO:0051489; P:regulation of filopodium assembly; IBA:GO_Central.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13202; FERM_C_MyoX; 1.
DR CDD; cd17206; FERM_F1_Myosin-X; 1.
DR CDD; cd13296; PH2_MyoX; 1.
DR CDD; cd13297; PH3_MyoX-like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR031971; MYO10_CC.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041797; MyoX_FERM_C.
DR InterPro; IPR040640; MyoX_N_SH3.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF2; UNCONVENTIONAL MYOSIN-X; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF16735; MYO10_CC; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF18597; SH3_19; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 62..741
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1197..1295
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1377..1481
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1531..1679
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1684..2030
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 822..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 954..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..981
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1013
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 156..163
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2047 AA; 235063 MW; 569F600C131041F2 CRC64;
MAFVLQGARV WLRENDQHLP CTVSSCSGGV VVFTTDYGQV YTYKQNTLTR QKVMPMHSSS
SEGVEDMAGL ADLHDGAIMY NLFLRYRQNK IYTYIGSILA AVNPYQFIPN LYDHPAVELY
SRHRLGEISP HIFAVANECY RSLWKRLENQ CVLISGESGA GKTESTKLIL KFLSAMSQHS
LEVTSKEKTS HVEQALLESS PIMEAFGNAK TVYNNNSSRF GKFVQLNFCQ KGNIQGGKIV
DCILFYNRVV RHNPGERNYH IFYALLAGTN AEQREAFYLS QPDSYYYLKQ SGCIEDKTIN
DKNTFHEVLN AMKTMQFSAE NIQEILRLLA GILHIGNVEF MTAGGAQVSS KSALGRAAEL
LGLDSGQLAE VLTHRSMILR GEEISTPLTV EQAVDSRDSM AMALYSQCFT WIIRKLNSRI
RGKEDFKSIG ILDIFGFENF EVNRFEQFNI NYANEKLQEY FNKHIFSLEQ LEYNNCGLCV
IFITIPMPGM LLGLEEHPHL ESKQSNSYLQ RSVDNCTVDK EGSSYLRNWS FPMETSDREL
VHYSYTKHWL GLIYYTEKDT LERNNRDFVR LNCILEVKKK KLSFFFCLFL NTHPNSGTVS
LRQSEARQYR PIASFPLPCG AYKCPTQISL SMGRFLKILL CSTHLMPERF DQPVVLNQLR
YSGMLETVRI RRAGFPVRRP FQDFYFRYKV LMKDVTLPED MKGKCACLLH LYDSTKTEWQ
LGKTKVFLRE SLENKLEKQR EVEVYKAAMI IQAHIVGYVA RKQYQRLLQC IVVIQKNYRA
FYWRRRFLHL RWAALTLQTR ARGHLARKTY YRLLEERRKR EEEERRQREE EEERERQRLE
AERLAQEAEA SRRAEEEEEE ERARAKGAGV REQRCPDSTQ VEEILRLERE IQELQRKKEQ
QELSLTQASL LRLQLLRDEE LRRLEDEACR AAQEFLASLN FDEIDECVRD IESSLSAGGQ
PYPREEEEGE GEEEVDEGFG ADDDAFKDSP NPSEHGHSDV RTSGIRTSDD SSEEDPYMND
TVVPTISGAA DALALPAAPG CQSGSNSGDS AYCMPENLGL MAQDSVELIP PNEDSDYDQD
DYDEGAIVSG SSVAFSNPHS GQWSSDYRCS VGTYNSSGAY RFSSEGAQSS YEDSEDDFDR
FDTDDELSYR RDSVYSCVTL PYFHSFLYIK GGLMNTWKRR WCVLKDETFL WFRSKQEALK
QGWLHKKGGG SSTLSRRNWK RRWFVLRQSK LMYFDSDGEE KLKGTLDVRS AKEIIDNTGK
ENGIDVVMPE RTYHLIAESA EDASQWFSVL SQVHGSTEQE IREMHDEQAN PQNAVGTLDV
GLIDSVCASD NPERPNSFVI ITANRVLHCN ADTPEEMHHW ITLLQRSKGD TRVEGQEFIV
RGWLHKEMKN STKASLKLKK RWFLLTHNSL DYYKSSERNA VKLGTLVLNS LCSVVPPDEK
VFKETGYWNV TVYGRKHCYR LYTKLLNEAT RWSSTIQNVI DTKAPIDTPT QQLIQDIKEN
CLNADVVEQI YKRNPILRYT HHPLHSPLLP LPYGDISLNL LQDKGYTTLQ DEAVKVFNSL
QHLESAGDPI PITQGILQTG HDLRPLRDEL YCQLIKQTTR PAQPGGVGNL RAWHILACMS
CTFTPSRGIL KYLKFHLKRT RELFPGTDME KYAAFTYESL KKTKTREFVP SQEEIKAIIS
RQEMTTTVYC HGGGSCKITI NSHTTAGEVV EKLIRGLAME DSRNMFALFE HNATIDKAII
VREKLSARYM VYGEKLSGNQ EESNKGWKFY FKLYCFLDTD NVPKDSVEFA FMFEQAHEAV
IRGHYPAPEE TLQFLAALRL QYLLGDFNAQ ASVPEMEQVY PMSRLRARIH QSTKTFAPAA
ERAEKKRASF LEGTLRRSFR SGSVSRQRLE EEQMLEMWVK EEIVAARTNV LEKWKKLQSM
TQEQAMVKYM ALVKEWPGYG STLFEVESRE GGFPSELWLG VSAEAISLYK RGEPRPLEVF
QYEHILSFGA PLPNMYKIAV EDRELLFETS QVVDVAKLMK AYISMIVKKR YSTTRSVSSQ
GSQCSSR
//
