ID W5N511_LEPOC Unreviewed; 843 AA.
AC W5N511;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015720.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000015720.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR EMBL; AHAT01002467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01002468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5N511; -.
DR Ensembl; ENSLOCT00000015750.1; ENSLOCP00000015720.1; ENSLOCG00000012757.1.
DR GeneTree; ENSGT00950000182881; -.
DR HOGENOM; CLU_005230_0_0_1; -.
DR Proteomes; UP000018468; Linkage group LG9.
DR Bgee; ENSLOCG00000012757; Expressed in camera-type eye and 3 other cell types or tissues.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF90; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 399..425
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 445..462
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 542..563
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 569..592
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 632..652
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 778..801
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 51..128
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 843 AA; 96655 MW; CD687D8AE3DA48D4 CRC64;
MGSFFRSEEM CLVQLFFQTE SAHYCINELG DLGLVQFKDL NPGTVAFQKR FVNEVKKCEE
MERILRFLEK EILKTNITIS ESCENVKAPC PRDVLELGAT FQKLEQELKE INSNHEALKQ
NFTEMMEMKY LLQMTEDFFE ENELPNILRE RNILLDRDYP IQRGPLRLGF VAGVIKQERF
PAFEKVLWRM FHGNFVLRHA EIQAPSEDFV GEELVKKDIF IVFLQGEQFK GKTRKICEGF
QASLYPCPDT VHARMEMRTS VDLRIEDLQT VLRQTDEYRE SILTSTAASL HEWNTKVKKM
KAIYYTLNLC NLDITQKLII AEIWCPASDL TKVNAALIKG CEQSGSSLCP VLNRLETQQI
PPTFNRTNSF TSGFQNIIDA YGVGNYQEMN PAPYTIITFP FLFAVMFGDC GHGLIMTLFA
TWMVIQEEQF KKFKNEISDI LFNGRYIILL MGIFSIYTGF IYNDCFSKAF NIFGSSWRVK
PMFHPNGPWS NQTLHGSGIL QLDPVTPGVF SGSPYPFGID PIWNIASNKL TFLNSYKMKM
SVILGVIHML FGVSLSLMNY TYFKNTRNIL LQFIPEVVFM LSLFGYLIFL IIFKWCSVLE
PETAPSILLL FINMVLFTYS DSSDNMLYNG QRGVQTFLVI TALLMVPWML LIKPLLLYRE
QKIIKQQVVY YTENFGIQKV SLNKMSLCSN SVYSNSQPEQ EDDEMNAFCK TNNHEEEKVS
MGDVIVYQAT HTIEYCLGCI SNTASYLRLW ALSLAHAELS EVLWKMVLQV GLTIGSRLGC
LVVAAIFAVF AVLTVAVLLV MEGLSAFLHA LRLHWVEFQN KFYKGSGYKF APFSFGHLLG
TND
//
