ID W5N5F1_LEPOC Unreviewed; 787 AA.
AC W5N5F1;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Cadherin-20 {ECO:0000256|ARBA:ARBA00040456};
GN Name=CDH20 {ECO:0000313|Ensembl:ENSLOCP00000015860.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015860.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000015860.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They
CC preferentially interact with themselves in a homophilic manner in
CC connecting cells; cadherins may thus contribute to the sorting of
CC heterogeneous cell types. {ECO:0000256|ARBA:ARBA00037319}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AHAT01002396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5N5F1; -.
DR Ensembl; ENSLOCT00000015890.1; ENSLOCP00000015860.1; ENSLOCG00000012876.1.
DR GeneTree; ENSGT00940000158167; -.
DR Proteomes; UP000018468; Linkage group LG9.
DR Bgee; ENSLOCG00000012876; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027:SF84; CADHERIN-20; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 610..631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..154
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 155..263
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 264..378
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 379..483
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 483..605
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 787 AA; 88221 MW; B5A0637A64AAED91 CRC64;
LKLGNKDNYY NFLQYSTLHI YFQIVSKSEI FKTSTQTDWT EPHNRVKRGW VWNQFFVLEE
YTGLEPLYVG KLHSDMDKGD GSIKYILSGE GAGTMFTIDD NTGDIHAIQR LDREEKAQYI
LRAQALHRQT GKPLEPESEF IVKIQDINDN EPKFLDGPYT ASVPEMSVIG TSVMQLTATD
ADDPTYGNSA RVVYSILQGQ PYFSVEPRTG IIRVSLPNMD REAKEHYEVI IQAKDMGGQL
GGLAGTTTVN VTLEDVNDNP PRFAQKLYQM SVPESAPVGS IVGRVQAKDL DEGINAEMRY
AIIDGDGRDT FDISTDPTNQ FGIISIRKKL DFESKRSFTL KVEGANTYLD PRFLNRGPFS
DVTIIHVSVE DVDEPPQFDS PHYFVEVPED VEIGTVFQTV SAKDPDVANN TVRYSIERKS
DPGRYFYIDI TSGALMTARP LDREELSWHN ITVLAMEMNN PTQIGSVSVT IKVLDVNDNP
PELAKYYEAF VCENAKAGQL IQTVTAVDLD DPLGGQHFYY SLAPEAANNP NFTLRDNQDN
TAWILTRRGG FTQKEQSIYH LPIFITDGDQ PMQSSTSTLT IRVCSCDSDG NVMSCTAEAY
TLPVSLSRGA LIAILACIFV LLVMILLILS LRSQRKKPYL SDEEENVHEN IVRYDDEGGG
EEDTEAFDIA AMWNPREVHL GKIRQDMLPE IESLSRYVPQ TCMGDSNVHG YVLAKLYEAD
ADPCAPPYDS LQTYAYEGEG SVAESLSSLQ SVTSNTDHEY DYLSDWGPRF KKLAEMYGVM
EANNPLW
//
