ID   W5N5N5_LEPOC            Unreviewed;       354 AA.
AC   W5N5N5;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Homer scaffold protein 2 {ECO:0000313|Ensembl:ENSLOCP00000015944.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000015944.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000015944.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC       {ECO:0000256|ARBA:ARBA00034103}.
CC   -!- SIMILARITY: Belongs to the Homer family.
CC       {ECO:0000256|ARBA:ARBA00023606}.
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DR   EMBL; AHAT01026081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015198440.1; XM_015342954.1.
DR   AlphaFoldDB; W5N5N5; -.
DR   STRING; 7918.ENSLOCP00000015944; -.
DR   Ensembl; ENSLOCT00000015974.1; ENSLOCP00000015944.1; ENSLOCG00000012948.1.
DR   GeneID; 102698071; -.
DR   KEGG; loc:102698071; -.
DR   CTD; 9455; -.
DR   eggNOG; ENOG502QR3K; Eukaryota.
DR   GeneTree; ENSGT00940000157324; -.
DR   HOGENOM; CLU_033940_0_0_1; -.
DR   InParanoid; W5N5N5; -.
DR   OMA; VHREITN; -.
DR   OrthoDB; 5490527at2759; -.
DR   Proteomes; UP000018468; Linkage group LG3.
DR   Bgee; ENSLOCG00000012948; Expressed in heart and 12 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR   GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IBA:GO_Central.
DR   GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:2001256; P:regulation of store-operated calcium entry; IBA:GO_Central.
DR   CDD; cd01206; EVH1_Homer_Vesl; 1.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR045027; Homer.
DR   InterPro; IPR044100; Homer_EVH1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000697; WH1/EVH1_dom.
DR   PANTHER; PTHR10918; HOMER; 1.
DR   PANTHER; PTHR10918:SF2; HOMER PROTEIN HOMOLOG 2; 1.
DR   Pfam; PF00568; WH1; 1.
DR   SMART; SM00461; WH1; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50229; WH1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT   DOMAIN          1..110
FT                   /note="WH1"
FT                   /evidence="ECO:0000259|PROSITE:PS50229"
FT   REGION          113..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          180..318
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        113..127
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   354 AA;  40100 MW;  39593B45ECA58536 CRC64;
     MGEQPIFTTR AHVFQIDPTT KKNWVPASKQ AVTVSYFYDS TRNSYRIISV DGTKVIINST
     ITPNMTFTKT SQKFGQWADS RANTVFGLGF ASEQQLAKFA EKFQEVKEAA KLARDKSQEK
     IETSSNHSQE SGRETPSSTQ ASSINGTDDE KISHGGPVDT QLKSENDRLK TALAQGSTNA
     KKWETELQTL RDSNARLIDA LQESASNVEQ WKKQLAVCKE ESDQLRNKIT ELEAQCAEAN
     LEKERNVQLG VRVRELESEL QEKEQELESL RKQAEIIPQL MEECESVSQK LQAAERKNKD
     LEDRMETLRA DIDESHHKQG HLKVELKKFL DVLDGKIDEL HEFRQGLSKL GIDN
//