ID   W5N5X1_LEPOC            Unreviewed;       616 AA.
AC   W5N5X1;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=NPL4 homolog, ubiquitin recognition factor {ECO:0000313|Ensembl:ENSLOCP00000016030.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000016030.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000016030.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NPL4 family.
CC       {ECO:0000256|ARBA:ARBA00011025}.
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DR   EMBL; AHAT01000404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006635231.1; XM_006635168.2.
DR   AlphaFoldDB; W5N5X1; -.
DR   STRING; 7918.ENSLOCP00000016030; -.
DR   Ensembl; ENSLOCT00000016060.1; ENSLOCP00000016030.1; ENSLOCG00000013007.1.
DR   GeneID; 102692221; -.
DR   KEGG; loc:102692221; -.
DR   CTD; 55666; -.
DR   eggNOG; KOG2834; Eukaryota.
DR   GeneTree; ENSGT00390000018731; -.
DR   HOGENOM; CLU_017172_2_0_1; -.
DR   InParanoid; W5N5X1; -.
DR   OMA; KWSRTGR; -.
DR   OrthoDB; 5400828at2759; -.
DR   Proteomes; UP000018468; Linkage group LG10.
DR   Bgee; ENSLOCG00000013007; Expressed in muscle tissue and 13 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd08061; MPN_NPL4; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR016563; Npl4.
DR   InterPro; IPR007717; NPL4_C.
DR   InterPro; IPR024682; Npl4_Ub-like_dom.
DR   InterPro; IPR007716; NPL4_Zn-bd_put.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR001876; Znf_RanBP2.
DR   InterPro; IPR036443; Znf_RanBP2_sf.
DR   PANTHER; PTHR12710; NUCLEAR PROTEIN LOCALIZATION 4; 1.
DR   PANTHER; PTHR12710:SF0; NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG; 1.
DR   Pfam; PF05021; NPL4; 1.
DR   Pfam; PF11543; UN_NPL4; 1.
DR   Pfam; PF05020; zf-NPL4; 1.
DR   PIRSF; PIRSF010052; Polyub_prc_Npl4; 1.
DR   SMART; SM00547; ZnF_RBZ; 1.
DR   SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50249; MPN; 1.
DR   PROSITE; PS01358; ZF_RANBP2_1; 1.
DR   PROSITE; PS50199; ZF_RANBP2_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00322};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322}.
FT   DOMAIN          234..371
FT                   /note="MPN"
FT                   /evidence="ECO:0000259|PROSITE:PS50249"
FT   DOMAIN          588..616
FT                   /note="RanBP2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50199"
SQ   SEQUENCE   616 AA;  68779 MW;  9FEED3EFBBB0AB47 CRC64;
     MAESIIIRVQ SPEGMKKIFA TKRETAASFL KKVAKEFGFS TNGFSIYLNR NKTGEIVSQS
     KSLSLLKIKH GDMLFLFPSA SPGPSGEVMD VAVPHSSSSS LSVLSRPQTS SQVTEDDIDQ
     YLAKQDGKIY RNQDPQLCRH GPMGKCVHCV PLEPFDEDYL NHLDPPVKHM SFHAYIRKLT
     GGADKGKFVA LENISCKIKS GCEGHPPWPE GICTKCQPSA ITLNRQKYRH VDNIMFENHT
     IADRFLDFWR KTGNQRIGFL YGRYTEHKDI PLAIRAEVAA IYEPPQIGTQ NSLELLEDPK
     AGAVEEIAAK LGLCKVGWIF TDLLSEDTRI GTVRYTRHKD SYFLSAEECI TAGDFQNKHP
     NPCRLSPDGD FGSKFVTVVA TGGPDNQVHF EGYQVSNQCM ALVRDECLLP CRDAPELGYA
     KESSTEQYVP DVFYKDKDKF GNDITYLARP LPVEYLIIDI TTTFPKDPVY TFTSTHRFPI
     ENRDVLGETQ DYHSLATYLS QCSSSVFLNI VSDFHLLLFL VTNEVMPLRD SIGLLLDAVK
     TSNEELAQTW KKSEQWATIE QLCSTVGGQP TGLHDYGAIG GPSVPASSSS MWSCRHCTFM
     NQPGTEHCEM CSLPRS
//