ID W5N6U0_LEPOC Unreviewed; 1079 AA.
AC W5N6U0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Semaphorin 6D {ECO:0000313|Ensembl:ENSLOCP00000016349.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000016349.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000016349.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AHAT01026095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006628709.1; XM_006628646.2.
DR RefSeq; XP_015198410.1; XM_015342924.1.
DR RefSeq; XP_015198411.1; XM_015342925.1.
DR RefSeq; XP_015198412.1; XM_015342926.1.
DR RefSeq; XP_015198413.1; XM_015342927.1.
DR RefSeq; XP_015198414.1; XM_015342928.1.
DR RefSeq; XP_015198415.1; XM_015342929.1.
DR AlphaFoldDB; W5N6U0; -.
DR STRING; 7918.ENSLOCP00000016349; -.
DR Ensembl; ENSLOCT00000016379.1; ENSLOCP00000016349.1; ENSLOCG00000013259.1.
DR GeneID; 102691531; -.
DR KEGG; loc:102691531; -.
DR CTD; 550377; -.
DR GeneTree; ENSGT00940000159303; -.
DR HOGENOM; CLU_009051_2_0_1; -.
DR OMA; EAYNHAX; -.
DR OrthoDB; 5399685at2759; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR Bgee; ENSLOCG00000013259; Expressed in brain and 11 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF65; SEMAPHORIN-6D; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1079
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867290"
FT TRANSMEM 662..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..513
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 579..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 800..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1027..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1079
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1079 AA; 119775 MW; 08382D1C4C897AB3 CRC64;
MGQRIQFFLG LVLLATSRLL ALSFPEDAEP LDTVDYQYSK QYAAFRGRPS GNESQHRLDF
QLMIKIQDTL FIAGRDQVYS VSLRETYRNE IIPYRKLTWR SGQADRETCA MKGKHRDECH
NFIKVLVPRN EDLVFICGTN GFNPMCRYYR LDTLEFDGEE ISGLARCPFD AKQTNVALFA
DGKLYSATVA DFLASDAVIY RSMGDGSALR TIKYDSKWLK EPHFLHAVDY GNYVYFFFRE
IAVEHNNLGK AVYSRVARIC KNDVGGSQRV LEKHWTSFVK ARLNCSVPGE SFFYFDVLQS
ITDIIEINGI PTVIGVFTTQ LNSIPGSAVC AFSMADIEKV FRGRFKEQKT PDSVWTAFPE
DKLPKPRPGC CAGQGLAEAY KTSIDFPDET LSFIKSHPLM DSAVPSVGEE PWFTKTRVRY
RLTAVAVDNS AGPRQNYTIV FIGSEAGVVL KVLAKTAPFS LNDSVLLEEI DVFNRAKCIS
NTEEDRKVVM LHLDKENHGL FVAFSSCVIR IPLSRCERHS TCQKACIASR DPYCGWMAHG
SCENLQPGIS SGYEQDVEYG NTVRLGDCHE VLATTSTPDY KTFGDPTSDM ELSSPPVTTM
ASGPIESPQI IDSQKPELFG SRKFVLQDDP ATSRSFDSLP GVPKGVWDVQ SGESNQMVHM
NVLITCVFAA FLLGAFIAAV VVYCYRDAFL RKSRKIHKDA ESAQSCTDSS GSFAKLNGLF
DSPVKEYQQN IDSPKLYTNL LSNGKDSAPS GDTKTMILSS QCQPPELAAL PTPESTPVLQ
QKTLQPIKNQ WEKAHNKINA SRKDSPLKSP QYFPASPPPH SPMGHSHIPS AVVLPNATHD
YRASFSNTDV LRSERKMQNI DQPASGKPSK KDHRRSVDAR NTLNDLLKHL NETNSGSKAI
LGDIPMTRQN LMLDPMANMT EVPPKVPSRE ASLYSPSSTL PRNSPTKRVD VPTTPVTSAV
QMSTLERQRG YHRNSSQRHS ISALPKNINS PNGIVLSRQP SMNRGGYVPP TPPSRMDSHG
APVGHPQPSI SRQSSYSGQG SLPRTGIKRT PSIKPDVPPK PNGFVPQTTQ VRAVNKYSY
//
