ID W5N732_LEPOC Unreviewed; 124 AA.
AC W5N732;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Vesicle-associated membrane protein 2 {ECO:0000256|ARBA:ARBA00013912};
DE AltName: Full=Synaptobrevin-2 {ECO:0000256|ARBA:ARBA00031647};
GN Name=VAMP2 {ECO:0000313|Ensembl:ENSLOCP00000016441.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000016441.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000016441.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004143}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004143}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family.
CC {ECO:0000256|ARBA:ARBA00008025}.
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DR EMBL; AHAT01030188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01030189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01030190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5N732; -.
DR STRING; 7918.ENSLOCP00000016441; -.
DR Ensembl; ENSLOCT00000016471.1; ENSLOCP00000016441.1; ENSLOCG00000013337.1.
DR eggNOG; KOG0860; Eukaryota.
DR GeneTree; ENSGT00940000158370; -.
DR HOGENOM; CLU_064620_4_0_1; -.
DR InParanoid; W5N732; -.
DR OMA; LLVYIWP; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000013337; Expressed in camera-type eye and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0017075; F:syntaxin-1 binding; IBA:GO_Central.
DR GO; GO:0035493; P:SNARE complex assembly; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR CDD; cd15870; R-SNARE_VAMP2; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR InterPro; IPR001388; Synaptobrevin-like.
DR InterPro; IPR016444; Synaptobrevin/VAMP.
DR InterPro; IPR042855; V_SNARE_CC.
DR PANTHER; PTHR45701; SYNAPTOBREVIN FAMILY MEMBER; 1.
DR PANTHER; PTHR45701:SF5; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SUPFAM; SSF58038; SNARE fusion complex; 1.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU00290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 101..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 39..99
FT /note="V-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50892"
FT REGION 13..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 124 AA; 13609 MW; B1702C5BE3DF9293 CRC64;
CFDCLIDRSA PAAAPAAAPG EGGAPPAPQQ PPNLTSNRRL QQTQAQVDEV VDIMRVNVDK
VLERDQKLSE LDDRADALQA GASQFETSAA KLKRKYWWKN LKMMIILGVI CAIILIIVIV
YFST
//
