ID W5N794_LEPOC Unreviewed; 907 AA.
AC W5N794;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Glutamate metabotropic receptor 7 {ECO:0000313|Ensembl:ENSLOCP00000016503.1};
GN Name=GRM7 {ECO:0000313|Ensembl:ENSLOCP00000016503.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000016503.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000016503.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; AHAT01029289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015203398.1; XM_015347912.1.
DR AlphaFoldDB; W5N794; -.
DR STRING; 7918.ENSLOCP00000016503; -.
DR Ensembl; ENSLOCT00000016533.1; ENSLOCP00000016503.1; ENSLOCG00000013382.1.
DR GeneID; 102684792; -.
DR KEGG; loc:102684792; -.
DR CTD; 2917; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234648; -.
DR HOGENOM; CLU_005389_0_0_1; -.
DR InParanoid; W5N794; -.
DR OMA; SANRTSC; -.
DR OrthoDB; 5388627at2759; -.
DR Proteomes; UP000018468; Linkage group LG5.
DR Bgee; ENSLOCG00000013382; Expressed in brain and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001642; F:group III metabotropic glutamate receptor activity; IBA:GO_Central.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR CDD; cd15451; 7tmC_mGluR7; 1.
DR CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001883; GPCR_3_mGluR7.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF98; METABOTROPIC GLUTAMATE RECEPTOR 7; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01057; MTABOTROPC7R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..907
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867150"
FT TRANSMEM 582..608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 746..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 779..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 821..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 582..856
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 866..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 101438 MW; B2A671DA3EE0DE2D CRC64;
MASFGTAFKP YFLWRALWVA KVVVELTLSQ EIYAPHSIRI EGDLTLGGLF PVHARGTPGM
PCGDIKKENG IHRLEAMMYA LDQINSDDEL LPNITLGARV LDTCSRDTYA LEQSLTFVQA
LIQKDTSDVR CTNGEPPVFV KPEKVVGVIG ASASSVSIMV ANILRLFQIP QISYASTAPE
LSDDRRYDFF SRVVPPDSFQ AQAMVDIVKA MGWNYVSTVA SEGSYGEKGV EAFIQISREA
GGICIAQSLK IPHEHKQSDF DKIIRNLLET RHARTVVIFA NDEDIRGILN ASKRANQVGH
FLWIGSDSWG AKYSPIHQLE DAAVGAVTIL PKRATIEGFD AYFTSRTLEN NRRNVWFAEY
WEENFNCKLM SSSKKEDTSR KCTGQERIGQ DSKYEQEGKV QFVIDAVYAM AHALHNMQKD
LCPDYSGVCP EMELAGGKKL LKYIRNVSFN GSAGTSVTFN KNGDAPGRYD LFQYQMTNNS
APGYKVIGQW MDSLQLNVDD MQWPNGEQDI PSSVCSLPCE MGYRKKMVKG MPCCWHCEPC
DGYQYQYDET TCKLCAYNMR PNENRTGCQP IPIVKLEWHS PWAVIPVFLA MLGIIATIFV
MATFIRYNDT PIVRASGREL SYVLLTGIFL CYIITFLMIA KPDVAVCSFR RIFLGLGMCI
SYAALLTKTN RIYRIFEQGK KSVTAPRLIS PTSQLAITSS LISVQLLGVF IWFGVDPPNT
IIDYDEQKTI NPDQARGVLK CDITDLQIIC SLGYSILLMV TCTVYAIKTR GVPENFNEAK
PIGFTMYTTC IVWLAFIPIF FGTAQSAEKL YIQTTTLTIS MNLSASVALG MLYMPKVYII
IFHPELNVQK RKRSFKAVVT AATMSSRLSH KPSDRPNGEA KTELCENVDP NSPAAKKKYV
SYNDLVI
//
