ID   W5N8K6_LEPOC            Unreviewed;       876 AA.
AC   W5N8K6;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   SubName: Full=Karyopherin subunit beta 1 {ECO:0000313|Ensembl:ENSLOCP00000016965.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000016965.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000016965.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC       subfamily. {ECO:0000256|ARBA:ARBA00010907}.
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DR   EMBL; AHAT01030904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_006638451.2; XM_006638388.2.
DR   AlphaFoldDB; W5N8K6; -.
DR   Ensembl; ENSLOCT00000016995.1; ENSLOCP00000016965.1; ENSLOCG00000013753.1.
DR   GeneID; 102697763; -.
DR   KEGG; loc:102697763; -.
DR   CTD; 3837; -.
DR   GeneTree; ENSGT00550000074898; -.
DR   HOGENOM; CLU_008296_1_0_1; -.
DR   OrthoDB; 124901at2759; -.
DR   Proteomes; UP000018468; Linkage group LG15.
DR   Bgee; ENSLOCG00000013753; Expressed in ovary and 13 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00185; ARM; 3.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT   DOMAIN          21..101
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          129..169
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          409..446
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   876 AA;  97391 MW;  6CC2844CC4B8F3BB CRC64;
     MELITILEKT VSPDRNELEA AQKFLEQAAI ENLPTFLVEL SKVLANPGNS QVARVAAGLQ
     VKNSLTSKDP DVKTQYQQRW LAIDANARRE IKNYVLQTLG TETYRPSSAS QCVAGIACAE
     IPVNQWPELI PQLVANVTDP NSTEHMKEST LEAIGYICQD IDPEQLQDNA NQILTAIIQG
     MRKEEPSNNV KLAATNALLN SLEFTKGNFD KETERHFIMQ VVCEATQCPD TRVRVAALQN
     LVKIMSLYYQ YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA
     SEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLATCCE
     DDVVPHVLPF IKEHIKHQDW RYRDASVMAF GSILEGPELN QLKPLVIQAM PTLIDLMKDP
     SVVVRDTTAW TVGRICELLP EAAINEVYLV PLLQCLIEGL GAEPRVASNV CWAFSSLAEA
     AYEAADAADD QEEPETYCLS SSFELIVQKL LETTDRPDGH QNNLRSAAYE ALMEIVKNSA
     KDCYPAVQKT TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA
     LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG SDFLKYMDAF KPFLAIGLKN
     YAEYQVCLAA VGLVCDLCRA LMSNILPYCD EIMQLLLENL GNENVHRSVK PQILSAFGDI
     ALAIGGEFKK YLDIVLDTLQ QASQAQVDKT DYDMVDYLNE LREGCLEAYT GIIQGLKGDQ
     ENVHPDVMLV QPRVEFILSF IHHIAEDEDH SDGVVANAAG LIGDLCTAFG KDVMKLVEVR
     PVINELLTEG RRSKTSKTKT LATWATKELR KLKNQA
//