ID W5N9C5_LEPOC Unreviewed; 1420 AA.
AC W5N9C5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Pleckstrin homology, MyTH4 and FERM domain containing H1 {ECO:0000313|Ensembl:ENSLOCP00000017234.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017234.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017234.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01022134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLOCT00000017265.1; ENSLOCP00000017234.1; ENSLOCG00000013964.1.
DR GeneTree; ENSGT00940000159456; -.
DR HOGENOM; CLU_001626_3_1_1; -.
DR Proteomes; UP000018468; Linkage group LG7.
DR Bgee; ENSLOCG00000013964; Expressed in zone of skin and 10 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13206; FERM_C-lobe_PLEKHH1_PLEKHH2; 1.
DR CDD; cd17178; FERM_F1_PLEKHH1; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22903:SF4; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 1; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 629..723
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 737..845
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 882..1036
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1047..1379
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 172..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 35..108
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 181..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1420 AA; 159375 MW; 8C5A56600ACFE9E5 CRC64;
MADVLENGGP VDWQKRCVAL ETQLLKFRLQ AGKIRELLAE KMQELEQRVT EADQRAESAE
KQVQVMEEKL KLANVQPSES ENSLYRRCQE LTNQIQEKDT MIKRLELQLE KQNVLRAQEA
KIIEEKAAKI KEWVTFKLRE LEIDNHQLRI ANLKQAEQIL VLQDKLQALL EGPGSPVGPR
SPTPETQSGL LSHSSPLFAS TSPSSPLAFE EGRKHSPSHF LPSPTLNTQV CYTDLKKKGL
DGLESLQNCS SPSPPLLGSH EKADLLPRSP CSVRKQTTQE VGKEAHSPVE KRGPSRGSER
DHSSDELNSK FRSQRLHSSS SSGETNIPSP VNTPVHSPKH STPSLASSLQ LVSPCPAAPF
GTSMTLPKVR TPLTPRDSIQ LAKKHYSQPQ PGTDKLHHIN VSIDISCFKP LAPAAQGPEE
TDIDEVPDKM DIEEHKSELA EERVSFIPLS EELELFDTDS LKPPTPPLHR FPSWEGRIYA
VAKSGMRLSE VTLGNWSPSR VSHLPLYAAA GPFTHLIYKN ISVPVYTTLK GTATQISSIP
FLDESSGSED DTSSLASLRT SALGPEAKKN SAPGSPRAVK RGVSMSSVSS ESDYAIPPDA
YSIDSDYSEP EHKLLRTSTY SCESACAEPL EKSGYLLKMG SQVKAWKRRW FVLRNGEILY
YKSPSDVIRK PQGQIELNSS CRIARGEGAQ TFQLITEKKT YYLTADSPNI LEEWIRVLQN
ILKVQAASPV VMETTAKPTV RGWLTKVKHG HSKLVWCSLI GKVFYYYRNQ DDKFPLGKLR
VREARVEEVD RSCDSDEDYE AGGRGFLSSH YTLVIYPKEQ SPTYLLIGTK QEKDAWLYHL
TVAAGSSGNL KVGTECEQLI GKLLDRDGDP DSPMWKHPVL CYSKEGLLSP LTTLPSEALQ
TEALKLFKSC QLFINVLVES PSIDYHMSLA QNALQVCLTH PELQNEIYCQ LIKQTSHRQP
QNYSLIQVWQ LLSVCVALFL PQHHFLWYLR VYLQRHADPR NEVGKYAIYC QRSVERTLQN
GDREAKPSRL EIMSILLRNP YHHSLPFSIP VHFMNSTYQV VGFDGSTTVD EFLNTLNQEA
GMRKPALSGF ALFTDDPSGK DLEHCLQGNV KICDVISKWE QALKELHPGK YEGTRIVRLT
YKSRMCFRAQ AKGEMERERL LLAYQVNDEV VHGRFPVNKE LALEMAALMS QVEHGDLDRP
VPSSPGGSSQ AKMQQLLLQA LDRFYPRRYR QDCTPEQLRR LADRLATKWM VLRGCSAAEC
VRIYLTVARK WSLFGAKLFT AKPVPPSPLE VAPLWLAVSE DGLSVLEYNT MHLVVTYSYQ
SVVTFGGCHD DFMIVVSQAK DRNSGKKTLE KLVFAMAKPK ILELTLLIAS YINYWTSNLL
SSSPHSPTPA HGTKGEKRLW DIDNRHFPSV PRTTKGPTLL
//
