ID W5NAH0_LEPOC Unreviewed; 855 AA.
AC W5NAH0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Solute carrier family 8 member 2a {ECO:0000313|Ensembl:ENSLOCP00000017629.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017629.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017629.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR EMBL; AHAT01029409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029410; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01029415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 7918.ENSLOCP00000017629; -.
DR Ensembl; ENSLOCT00000017661.1; ENSLOCP00000017629.1; ENSLOCG00000014315.1.
DR eggNOG; KOG1306; Eukaryota.
DR GeneTree; ENSGT00940000158344; -.
DR HOGENOM; CLU_012872_1_0_1; -.
DR InParanoid; W5NAH0; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000014315; Expressed in camera-type eye and 4 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0098794; C:postsynapse; IBA:GO_Central.
DR GO; GO:0042383; C:sarcolemma; IBA:GO_Central.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF8; SODIUM_CALCIUM EXCHANGER 2; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 1.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 680..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 757..777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..849
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 269..376
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 406..506
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT REGION 542..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 94083 MW; 3F96AA9FFE4FD9EE CRC64;
QEKEVTITKP NGETSVATVR IWNETVSNLT LMALGSSAPE ILLSVIEQAG NHLQRGAFGK
SPEPGSTAAP WVLFPESPLV HRVTPLRPGA QTSFSTAVSH CLNYSVCYPS THYPDFTVLL
LRFHCTALFC LYCSYRVFYF GLTVLHYRAD RRHGIVVEME GELTPKGVEM IMDDSCQEAN
SSASHPSNTL ITTASMETNR ELDESRKEVR IRFSIIISTK YCESRCTSWD TGSHFYSCMG
RKHSSTVHTR LALTAVLHRT TEIHRKASSC HTLSHSRPAL SAGFLMPALR CPGFSGLLLE
TDLVFPLALI XQGGAGASTF YVDYRTEDGS ANAGSDYEYS EGTLVFKPGE TRKEIQVGII
DDDIFEEDEH FFVRLLNLRV GDAEGMFESE DGPGGPKARL AEPAVTTVTI LDDDHAGIFT
FGERVLRVSE SVGTMEVSVL RNSGARGTVV LPYHTEEGSA KGGGVDYEDA RGELEFTDDQ
TSESEKVRIV DDEEYEKQEN FFIVLEEPRW LKRGISDITS RTSCDQLVRV ALLLTQGKRI
HSDSQPAATA PVPPHTGAPP LSEDPEGKLS AEEEEARRIA EMGKPVLGEH NRLEVIIEES
YEFKSTVDKL IKKTNLALVI GTHSWREQFI EAVTVSAGDG DEEDDEGREE RLPSCFDYVM
HFLTVFWKVL FACVPPTEYW NGWACFLVSI TVIGLLTAVI GDLASHFGCT VGLRDTVTAV
VFVALGTSIP DTFASKVAAT QDQYADASVG NVTGSNAVNV FLGIGVAWSV AAIYWNVQGK
TFRVDPGSLA FSVTLFTIFA FVNIGVLMFR RRPSIGGELG GPRVAKLLTT LLFFGLWFLY
ILFSSLVAYC HIEGF
//
