ID W5NAU9_LEPOC Unreviewed; 1039 AA.
AC W5NAU9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Toll-like receptor 9 {ECO:0000256|ARBA:ARBA00017400};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017758.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017758.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000256|ARBA:ARBA00004177}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; AHAT01014872; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NAU9; -.
DR STRING; 7918.ENSLOCP00000017758; -.
DR Ensembl; ENSLOCT00000017790.1; ENSLOCP00000017758.1; ENSLOCG00000014430.1.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000163875; -.
DR HOGENOM; CLU_006000_2_0_1; -.
DR InParanoid; W5NAU9; -.
DR OMA; YNQNFCR; -.
DR Proteomes; UP000018468; Linkage group LG5.
DR Bgee; ENSLOCG00000014430; Expressed in bone element and 2 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0038187; F:pattern recognition receptor activity; IBA:GO_Central.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IBA:GO_Central.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF3; TOLL-LIKE RECEPTOR 9; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00368; LRR_RI; 5.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1039
FT /note="Toll-like receptor 9"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004869492"
FT DOMAIN 875..1019
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1039 AA; 115453 MW; E76F84898CF7C9C3 CRC64;
SSPQASPRGA AALPGFLAVL VSLLPPGAAT YPPFLPCGSP SPQTVDCAAH GLTRVPLFRA
PTGAVTALLL SGNHISRIPA DAFALFRRLE TLELQWNGLL RPGVPKAGGP MVLAPRAFEP
LAQLRSLDLR GNGLRAVPLL PPSLRTLDLS YNRLLLLEPP ARPPALAALQ TLRLDGNCYY
NNPCGHSQGA PRGFLAGMGR LRELSLGHNN LTAVPGGLPA GLRRLALHYN QISAVAPGDF
GQLARLSSLD LKGNCRRCEH APSPCIKCAR SALHLPAGCF ASLGSLKSLN LSDNSLASLN
DSVFAPLRGL EELLLSDNLL SRTSPNGNDL VLGSPAFRGF PRLRSLDLSY NYRRFTVFRR
LALTEDFAGL ARLQSLQITG CFFQSVDNAS VAPLAGLPEL RLLNLRLNFI KNIELHIFDS
LAGLSYLRLS DNEISCTRCR GAPGKRPGLP DHRLTPGSSL QARGLIAPEP QVGLPLPESC
TGRETLNLMR NNLVYVQKEL FEGFERIECL ILSHNSISQS FNGNQFILLK RLKLLDLSYN
RIDLYYKAAF SELPSLEVLD LSNNNYHFQL SGMGHRLDFI AGLPSLRLLD LGFDSISDRI
STALASSSLN KLVFRHNRLQ DMWNKKIYFQ FFRNLTNLTS LDLSNNLLTR IPPEGIYHLP
PTLRDLNLKF NKLTSFPWEA LSAFPCLEIL DLSYNWLSTL SRSLHPGSYI PPDSGLRSLN
LSSNRIHAID RDFFRNATAL ASLLLSDNQL EQLDFDNFLL QRLRVLDIRW NRLVCTCDSS
FYELFGNFNF SVPALTSQVT CGSPDKLRGR SVFSRDAPLC PGSRNMAAFL LSLALALPLT
ALPVLRQVLG WDAWYAFYVW VARAWGLFYK GGEGSAYDAF VAFDKEQESV ADWVYNELRV
QLEDSGAQRF RLCLEERDWL PGRSSIENLH EAVQGSRKTV FVLPRAGPAG GLLREAFFLA
QQRLLEERAD VAVFVLLEKG RRGSRYLQLR RLLCRETVLL WPQNPQAQGY FWHRLRCVLG
RDIQASYDRK HCRGVPTPL
//
