ID W5NAV4_LEPOC Unreviewed; 1160 AA.
AC W5NAV4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Integrin alpha-X-like {ECO:0000313|Ensembl:ENSLOCP00000017763.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017763.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017763.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AHAT01038658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01038659; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NAV4; -.
DR STRING; 7918.ENSLOCP00000017763; -.
DR Ensembl; ENSLOCT00000017795.1; ENSLOCP00000017763.1; ENSLOCG00000014415.1.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000154838; -.
DR InParanoid; W5NAV4; -.
DR OMA; ACGPTWE; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000014415; Expressed in camera-type eye and 12 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0008305; C:integrin complex; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0033627; P:cell adhesion mediated by integrin; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF84; INTEGRIN ALPHA-L; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 26..1160
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001426643"
FT TRANSMEM 1102..1125
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 156..328
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 445..505
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 507..565
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 569..632
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1160 AA; 125617 MW; 219FEAF8FFC5A90A CRC64;
MTSPRIKRSL WTLAVPLFYT HLCCCFNLDS QQPLVFHGEA AAHFGHRVCQ FGQAGNESVV
VSAPLQANRT GHVYSCRFGT GQCERISLPG TGDAGIAMGL TLACDNKQLA VCGPQLQHDC
DPIPYLNGFC VLLGPGFAVK ETLRPAFQEC RDSGLDAVIL FDDSQSISDT DFQTMIQFIK
DVLRNFTDPK SQVAVAQYST NIRTVFSFNT FVSNRNPNSL LRNVPHTQGQ THTPSAIKYV
LDNVFTKEQG MRQESKKLLV VITDGKSNDP KEKFENVIPL AESRGIIRYA IGVGKQISKQ
ELKTIASSPK DVFEVNSFEA LNSILKQLGE KIFAIEGTNK KSNFTSFQLE LSQGGFSAAV
TEESILFGAV GSFDWSGGFV EIRGGDLHGT FINASSREPE FADSYLGYAL AVAQLAEGRV
YFAGAPRHTH RGTVLGFKKG RSAWEVAWRL NGTQLGSYFG AELCVLDVTG DGRTDLLLIG
APLFHEPGTG GEVTVCTIAS EGFPNCSSSL RGSPGNEHGR FGTAIAATPD LDGDGIPDLA
VGAPHEDERG GSLYIFLGHR RGVHTQHSQK VQGASVRSGL QFFGQSVHSA GDLSWDGLAD
VAVGARGAAV VLSLPRSQPV INVSVAMTFT PNAITENNFH CARPIMSSTQ PATIATVCIA
ITAVHAGKLS SGLSARVNVS VRLEPQAKTS RLLFVPGDPT THWTGTVNDS ACYNISIIVP
ACISDYSPVP LSGNFTVEGE RMKVTDGLRP ILTPRCLTTF ADQVLLEQVC GEDQVCVSDL
GVTINFTSLS PMVIASPRYT VIVQVAITNL GEDAYGTEMA LIYHSALSFT KASVTQSTWR
SSLSCSGDDR QVNSTVVRRA SCQVSASVLK ERAKVTLHAF FTVSHPELLE DHLQLNVSVQ
SKNENLTLED NFDSSTVPVL LPVDIVVEES CVSSADSTYN IIFLETSQTS SNMEHSYKVK
NVGDVDLPVD MTFIVPVELR SGFVWNVSAP AEPIRQSMPC SLKQPYSWSP LTACSLPQFC
NGTLCLHFGC KIDRLTRNQE VTFTFLGNII RNPESQKNGV QVTAESWSFL SFDERKYIQF
PSSSVNRFSV NTVLEVPRQD SLVGIIVGSV IGGLVILIII SLAMAKMGFF KKFLQFVEKM
KAGNGLLVPN GKSSEERAAQ
//
