ID W5NBA7_LEPOC Unreviewed; 272 AA.
AC W5NBA7;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=catechol O-methyltransferase {ECO:0000256|ARBA:ARBA00012880};
DE EC=2.1.1.6 {ECO:0000256|ARBA:ARBA00012880};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017916.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017916.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Cation-dependent O-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00023453}.
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DR EMBL; AHAT01006616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NBA7; -.
DR STRING; 7918.ENSLOCP00000017916; -.
DR Ensembl; ENSLOCT00000017948.1; ENSLOCP00000017916.1; ENSLOCG00000014559.1.
DR eggNOG; KOG1663; Eukaryota.
DR GeneTree; ENSGT00940000155317; -.
DR HOGENOM; CLU_050461_5_0_1; -.
DR InParanoid; W5NBA7; -.
DR OMA; WNELVLQ; -.
DR Proteomes; UP000018468; Linkage group LG1.
DR Bgee; ENSLOCG00000014559; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0016206; F:catechol O-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0042424; P:catecholamine catabolic process; IBA:GO_Central.
DR GO; GO:0032502; P:developmental process; IBA:GO_Central.
DR GO; GO:0042417; P:dopamine metabolic process; IBA:GO_Central.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR002935; SAM_O-MeTrfase.
DR PANTHER; PTHR43836; CATECHOL O-METHYLTRANSFERASE 1-RELATED; 1.
DR PANTHER; PTHR43836:SF10; CATECHOL O-METHYLTRANSFERASE B; 1.
DR Pfam; PF01596; Methyltransf_3; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51682; SAM_OMT_I; 1.
PE 3: Inferred from homology;
KW Catecholamine metabolism {ECO:0000256|ARBA:ARBA00022939};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Neurotransmitter degradation {ECO:0000256|ARBA:ARBA00022867};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 272 AA; 30348 MW; CA41F9D7FF9BCE2E CRC64;
QMWLYGLCLV GGGLSLLYAL SRWLIPALAQ YNGSLALLWN DTILERALDL LTRSSRPQRM
LAHVKRHAAR GDPQSVIDAI DYFCRHKEWA MNVGDEKGTI LDSVVCEVSP GAVLELGTYC
GYSTMRIARL LAPGARLITL EFNPANAAVA RQVIAWAGLE HKVQLVEGSS GDLIPQMREK
FGIDSFDLVF LDHWKDWYLP DTRLMEELGL LHKGSVLLAD NVICPGAPEY LAYVRSSPRY
DSRYFKSHLE YTYVEDGLEK SVFPGASAGS RP
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