ID W5NBE4_LEPOC Unreviewed; 626 AA.
AC W5NBE4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Leucine-rich repeat and fibronectin type III domain-containing protein 1-like protein {ECO:0000313|Ensembl:ENSLOCP00000017953.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000017953.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000017953.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR EMBL; AHAT01023716; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NBE4; -.
DR STRING; 7918.ENSLOCP00000017953; -.
DR Ensembl; ENSLOCT00000017985.1; ENSLOCP00000017953.1; ENSLOCG00000014588.1.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000164973; -.
DR HOGENOM; CLU_016998_1_0_1; -.
DR InParanoid; W5NBE4; -.
DR OMA; EPALQPC; -.
DR Proteomes; UP000018468; Linkage group LG2.
DR Bgee; ENSLOCG00000014588; Expressed in brain and 2 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF5; LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..626
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867504"
FT TRANSMEM 522..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 296..384
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 415..511
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 626 AA; 69946 MW; CF197B4A301F1F5C CRC64;
LCLSRKLAME RLLICLVMLS APASAMLCPK RCMCQNLMPS YTVLCAKTGL LFVPPTIDKR
TAELRLMDNF ITTLRRKDFA NMTSLIHLTL SRNTISQIIP YTFSDLQELH ALHLDSNRLT
TLNDSHFQGL INLRHLILSN NQLQSIAEGS FEDFLETLED LDLSYNNLVD IPWDTISRLV
SVNTLSLDHN LIEFVPEGIF SNLHKLARLD MTSNKLKKIP PDPLFLRIPV YAKTKGSPLS
ALVLSFGGNP LHCNCELVWL RRLTREDDLE TCASPQELMG KYFWTIKEEE FICEPPMITR
HTSKMFVMEG QEVSLRCKSI GDPEPTIHWV SPEGKLIANT TRTTCYENGT LDILTTTIKD
SGIFTCIASN AAGESTAPVE LIVNPFPYFN PKIEPEPGPS DFPTSIKSNV TNSRQDQRVM
VTEVTSSSAT IKWNPQNHIP GIRMYQIQYN SSLDRILIYR MIPASGNLFL LSDLASSRDY
DLCVLAVYDD GITSLTATKL VGCVAFTTEK EYRQCRSIHD QFLGGTMIII IGGIIVASVL
VFIFILLMKY KVYNNHYKQK QAKVSNVCSQ TNGSHGGGSS SSSGKLAEKY DVQTQESYGG
TLKGTTVVDL NPNYGKAVTE DDDVSQ
//
