ID W5NC12_LEPOC Unreviewed; 1509 AA.
AC W5NC12;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Dispatched RND transporter family member 2 {ECO:0000313|Ensembl:ENSLOCP00000018171.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000018171.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000018171.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dispatched family.
CC {ECO:0000256|ARBA:ARBA00038046}.
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DR RefSeq; XP_006643132.2; XM_006643069.2.
DR STRING; 7918.ENSLOCP00000018171; -.
DR Ensembl; ENSLOCT00000018203.1; ENSLOCP00000018171.1; ENSLOCG00000014758.1.
DR GeneID; 102696811; -.
DR KEGG; loc:102696811; -.
DR CTD; 85455; -.
DR eggNOG; KOG3664; Eukaryota.
DR GeneTree; ENSGT00940000159551; -.
DR InParanoid; W5NC12; -.
DR OMA; MPVTIVW; -.
DR OrthoDB; 2875706at2759; -.
DR Proteomes; UP000018468; Unassembled WGS sequence.
DR Bgee; ENSLOCG00000014758; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0035195; P:miRNA-mediated post-transcriptional gene silencing; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR45951:SF2; PROTEIN DISPATCHED HOMOLOG 2; 1.
DR PANTHER; PTHR45951; PROTEIN DISPATCHED-RELATED; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 182..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1010..1029
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1035..1057
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1064..1088
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1108..1130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 535..667
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 103..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1289..1323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1394..1456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1469..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1289..1307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1406..1420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1432..1446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1495..1509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1509 AA; 165749 MW; A6BD229E3253A05A CRC64;
MDACSVSEEN AHVIIMDSSP AEGPEQETSL SEIPEVALCP PESPDREPRL TLIHTDGDRL
SSPGHPRTAS LSQLYHQVSQ GCSHQSPLLK RCRYCGHRQP VTSSLCPERH SGPASPRPDC
SSATVKTADS CSPSHVPSCH DTIHCHWLQG SHDAGNHQAM QHHVVTVRHE RLYRIPRSYS
QLVADCPVAL LITCAVVFLG CSLAGILTGP LPDFSDPLSG FEPRGTEIGR RLSAWNRLQE
NTGPEKTLSL SPRQLTEQRV ISYDEEGGGG TGKSRDWPSP RQRRMLDWDF TQDTFFCDSP
GEKYAQLVFR SGNSASLWSL QAIHSMCEME QARIRSHALF QDLCKHRGGE DGEGDTGMRE
CCPSWSLGNY LAVLSNATSC LGLSAAQVSE SLQLLRQCAP YYHDGSLAPA CAEKGKLGQC
STVPSQCKHS SAIYQILHYL VDKDFLGPQT IGYKVPSLKY SLLFLPVEKG DHMMDMYLDN
LEGRDLTNDN TTITGMDLGI KKQLFQYYLA RDSVYPVLAV VMLFLTMAFY LHSLFLSAMS
LAAILGSLMS SYFFYKVAFR LTFFPFLNLA ALLVLLGSCA NQAFIFADLW SLQLSQKPPA
SLEKRVKRAL QEAGYLILVS GLTSSAAFYS GYMSSITAVR CFAVYLGTAT LISSLSSLVW
LPCILILHER YAVAAAAVEA PAGKTCCALS PGGFWDTSSR KRCLFSLGQK LRGLRRGLTD
TSDLLFIKIL PCGVVKFRYI WVCWFAVLAA GGTYITCVDP GMKLPTLESK AAQLFRSSHP
FERYDAEYSH QFMFERLKSG EEKPMTITLV WGVLPTDNGD HLDPKSNGSL VLDPEFNMSS
PDAQSWLRDL CPRIQNQSFY LPISSSSEEE KQGDSVCFVE RLLRWVSIRQ CSESEGAYSL
CCNDILFPYL PGVFEHCLGM MAAEKEAEGF LFDTGGPRFD SEGRITALIL EFTTTHLHSY
NYSQSAHFYQ QIEAWFHREI SGAPPGLRNG WFVSQLALYD LQQCLSSETL VVTGFSVALV
FAMLLLTTWN IPLSIYGSAA VGGSVFVTAG LLVLLEWQLS GLEALFISAA AGLSVDFAAN
YCVSYSLSPH PDRLGRVAHS LKRMGCPAAI GAGAFFCMGI IMLPATALLF RKLGIFLLLV
KCVACGFATF FFQSLCCFFG PQKNCGQIFW PCTTASGHYK ADSESGNLLS TAAAGSSNSA
ANGAFGCGGR SRVRRSFGKA EGGGQLCPSQ QRQRQRQGGG GGRESEQYEL QPLACQLSDS
FENSTCTSKL SNRPSVLSEE IQFRSLSPRK DLEEFNTEDD SEELTSRHLK TFPPPPALQT
SSPYKENTLR PVVVPPSEMV QERLLCRRCR GQAGGIKHWN VSLSSSSSME DIIISSQPPD
MDHRHSLSIE GAMSSPFKRH PHRRLLSSQS QSSFEGLEDS NETCLSDVEP GPATPQPTTE
AQAESQPGYL NGKRDTLRLS LKETVFEASS QGIGRGRTSQ GELPVILPNS KPDLPDVWIK
REGRSGDGS
//
