ID W5NC27_LEPOC Unreviewed; 618 AA.
AC W5NC27;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Voltage-dependent calcium channel alpha-1 subunit IQ domain-containing protein {ECO:0000259|SMART:SM01062};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000018186.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000018186.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR EMBL; AHAT01006394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01006399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NC27; -.
DR STRING; 7918.ENSLOCP00000018186; -.
DR Ensembl; ENSLOCT00000018218.1; ENSLOCP00000018186.1; ENSLOCG00000014770.1.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000159855; -.
DR HOGENOM; CLU_442527_0_0_1; -.
DR InParanoid; W5NC27; -.
DR Proteomes; UP000018468; Linkage group LG1.
DR Bgee; ENSLOCG00000014770; Expressed in camera-type eye and 3 other cell types or tissues.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF2; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1F; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU003808};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT DOMAIN 341..375
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 528..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 594..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 68855 MW; 8AD823D8B125AD1F CRC64;
DIANKVLLSL FTLEMLLKMY SLGLQGYFVA FFNRFDCFVV CGGIMETILV EFGSSEDSSR
ISITFFRLFR VMRLVKLLSK GEGIRTLLWT FIKSFQVLTT VNTQVLYRLI LGLSSGVTFG
KIAMKDHTQI NRNNNFQTFP QAVLLLFRCA TGEAWQEIML ASLPGKRCDP ESDYEPGEEF
SCGSNFAIVY FISFFMLCAF LVRGQCPGAV GRGSGGHCSC RHPHRAGTVT RAPPQGWYSD
RCTPTGLVQS GGVSALALRL PVLFPHVLCT SAPGRGAPLR SAGAWAQAGG PDLVVLLPVS
LSLTCPGNPD QANEELRIVI RKIWKRMKPK ILDEVIPPPE EEEVTVGKFY ATFLIQDYFR
KFRKRKEKGM LGEPESNNSS ALQVSDGWRG LGGSVPSSSR HLLHTYSMID PDVVLEVALQ
NTTYQVTTVA HILFTLTAFL LLIDFWPQSI HRSCFPRMRV CSRRMVTTPP QAGVPRWPTR
LTLPTRRAVP AAPRPREFYG GTPARGTPLP VAGRRGCWRR WGRRPTLGSR VTTAERRTRR
AQPPETGHPP GHAPYGPHYG NGYREGCRTA RRRLLPATPT GRKPAFNIQC LRRQGSSDDI
PIPGTYHQNS PPCRARTQ
//
