ID W5NCP6_LEPOC Unreviewed; 345 AA.
AC W5NCP6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=POU domain protein {ECO:0000256|RuleBase:RU361194};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000018405.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000018405.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the POU transcription factor family.
CC {ECO:0000256|RuleBase:RU361194}.
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DR EMBL; AHAT01016846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NCP6; -.
DR Ensembl; ENSLOCT00000018437.1; ENSLOCP00000018405.1; ENSLOCG00000014949.1.
DR eggNOG; KOG1168; Eukaryota.
DR GeneTree; ENSGT00940000165106; -.
DR HOGENOM; CLU_013065_0_0_1; -.
DR InParanoid; W5NCP6; -.
DR OMA; HRRKMEN; -.
DR Proteomes; UP000018468; Linkage group LG7.
DR Bgee; ENSLOCG00000014949; Expressed in camera-type eye and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR013847; POU.
DR InterPro; IPR000327; POU_dom.
DR PANTHER; PTHR11636:SF44; BRAIN-SPECIFIC HOMEOBOX_POU DOMAIN PROTEIN 3; 1.
DR PANTHER; PTHR11636; POU DOMAIN; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00157; Pou; 1.
DR PRINTS; PR00028; POUDOMAIN.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00352; POU; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00035; POU_1; 1.
DR PROSITE; PS00465; POU_2; 1.
DR PROSITE; PS51179; POU_3; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transcription {ECO:0000256|RuleBase:RU361194}.
FT DOMAIN 192..269
FT /note="POU-specific"
FT /evidence="ECO:0000259|PROSITE:PS51179"
FT DOMAIN 285..345
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT REGION 99..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 38002 MW; 3AD76049A2FA3321 CRC64;
KKEVGLGVIM MSMNSKQAFS MHPILHEPKY TPLHSSSEAI RRACLPTPSL QGNIFAGFDE
TLLQRAEALA AVDIVSQKNH PFKPDATYHT MTSMTCTPTS SSAHLHHPSV LGSHHHHHHH
HQPSQGLEGD LLDHLTPAIS LGGMAGPDVG SSASHSHAHM SAINHMSHHH PQTMNMHPHG
LASHASLGSA GDSEPDPREL ESFAERFKQR RIKLGVTQAD VGSALANLKI PGVGCLSQST
ICRFESLTLS HNNMVALKPI LEAWLEEAER AQREKMTKPE IFSGGDKKRK RTSIAAPEKR
SLEAYFAVQP RPSSEKIAAI AEKLDLKKNV VRVWFCNQRQ KQKRM
//
