ID W5ND85_LEPOC Unreviewed; 936 AA.
AC W5ND85;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=dolichyl-phosphate-mannose--protein mannosyltransferase {ECO:0000256|ARBA:ARBA00012839};
DE EC=2.4.1.109 {ECO:0000256|ARBA:ARBA00012839};
GN Name=TMTC1 {ECO:0000313|Ensembl:ENSLOCP00000018594.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000018594.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000018594.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TMTC family.
CC {ECO:0000256|ARBA:ARBA00007882}.
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DR EMBL; AHAT01025629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025635; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025637; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01025638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5ND85; -.
DR STRING; 7918.ENSLOCP00000018594; -.
DR Ensembl; ENSLOCT00000018626.1; ENSLOCP00000018594.1; ENSLOCG00000015106.1.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00940000158027; -.
DR HOGENOM; CLU_011615_1_0_1; -.
DR InParanoid; W5ND85; -.
DR OMA; TRWHTWR; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000018468; Linkage group LG8.
DR Bgee; ENSLOCG00000015106; Expressed in ovary and 11 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004169; F:dolichyl-phosphate-mannose-protein mannosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0035269; P:protein O-linked mannosylation; IBA:GO_Central.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR013618; TMTC_DUF1736.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44809; -; 1.
DR PANTHER; PTHR44809:SF1; PROTEIN O-MANNOSYL-TRANSFERASE TMTC1; 1.
DR Pfam; PF08409; TMTC_DUF1736; 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 2.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF14559; TPR_19; 1.
DR SMART; SM00386; HAT; 5.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 109..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 353..425
FT /note="DUF1736"
FT /evidence="ECO:0000259|Pfam:PF08409"
FT REPEAT 544..577
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 609..642
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 643..676
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 677..710
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 744..777
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 812..845
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 850..883
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 884..917
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 104206 MW; 3CB64142D67A1C5A CRC64;
VISSAHARGG GGAQPLRQRR AGAPQKRYAL LVSVCALCYG NSLRGEFVHD DVWAIVNNPD
VRPGSSLRNI FFNDFWGKRM ADNTSHKSYR PLCILAFKLN ILLGGMTPLY FHVVNVLLHC
AVTALLMLAC ERTVFQDRRL AFLTALLFAV HPVHTEAVSG IVGRADVLAC LLFLLTFLSY
TRCVDHRGSG ECFPPTVSAG WLVLSLLLGT CAMLVKETGV TVFGVCVVYD VLVICQKPLV
SISGSKCERR PASPPVSSSG PAWQRGRAGD TNVYPHKQGV GGGSHSSLPR EMKSSGFNLC
PLSFECIYCC FKLRASEISQ RTFLRTLLEL LLAVVVVSEV AVIMSFRLWI MGGSMPLFSE
QDNPASFSPH LLTRLLTYSY LLAFNAWLLL APIVLCYDWQ VGSIPLLESV WDVRNAATCL
FGVAMVCLCL HCLASLQKLE NREVLVGILF LVFPFIPASN LFFRVGFVVA ERVLYMPSMG
YCILVVHGLS RLCSVVGRWG APALTLSLLL LLLLFSWKTV QQNETWLSRE ALFRSGIQTL
PHNAKVHYNY ANFLKDQGRN QEAIHHYETA LRLYPRHASA MNNLGTLTRG AEEAERHYRR
ALEINPQHNR ALFNLGNLLK ARGKEAEAEQ LLRDSVQLGP HFADAYSSLA SLLAEQGRFG
EANEVYLQGI ENCPDSSDLH NNYGVFLVDT GDGEGAAAHY QQAIQLKPSH FVAMVNLGRL
LRSSGQNREA EAWYRRALQV TRRVEILTPL GALYYNTGRY EEALQVYREA TELQPDNGEI
WLALAQVLAM AGQAKEAEEM TFGILSKNTA CVECYRLLSA IYSKRGSHNE ALDALEKAIQ
LNMGDLAMKA ELHFSKGNQL REMNLLEQAF QSYRMAVELN PDQSQAWMNM GGIQHIKGDY
VLARVYYEKA LQLSPGSRLL KENLAKLDRL EKRLQA
//