ID W5ND92_LEPOC Unreviewed; 1254 AA.
AC W5ND92;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0000259|PROSITE:PS50261};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000018601.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000018601.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR EMBL; AHAT01016976; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01016977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01016978; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5ND92; -.
DR STRING; 7918.ENSLOCP00000018601; -.
DR Ensembl; ENSLOCT00000018633.1; ENSLOCP00000018601.1; ENSLOCG00000015115.1.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000156341; -.
DR HOGENOM; CLU_002753_3_3_1; -.
DR InParanoid; W5ND92; -.
DR OMA; EIDITHD; -.
DR Proteomes; UP000018468; Linkage group LG7.
DR Bgee; ENSLOCG00000015115; Expressed in intestine.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd15997; 7tmB2_GPR112; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF277; ADHESION G-PROTEIN COUPLED RECEPTOR G4; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..1254
FT /note="G-protein coupled receptors family 2 profile 2
FT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004867591"
FT TRANSMEM 881..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 919..942
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 954..977
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 989..1010
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1041..1067
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1088..1110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1116..1137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 882..1139
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1166..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 138856 MW; 3717CBE75D026037 CRC64;
SIMQPSSCKV LLCCWVLSTV FILRSGAPSL RGQKVVLFGR QCSYWELRGS VSLPALDEFT
VCVDLCRKIN TRQWTAFTYN RPPQRLSEGA PELGLAGHGQ ALRLWLFGRA LDAPVDLRPF
AWHSVCLAWS GVEQKVWLYV NGSGVFSAAV PDRRPLAPHG TLTLGVAHGL IGGEIVTEDG
NNLIGEIYFF RMWDKQRSAQ QVSSQICAEG NVIRWTSEYW HNHSCSPVPD LSLPCASSFY
SINMSIYIMR RDGQSADETI AKDLVCLWLT TYFPANITVL AIAVFSLQQG WEITFPKMQI
VITAPASYGC FVSVKVIPSS EVLLTKEEVT RLLRGSVAHV ADSCCVVLPL HLLLCSCVLT
ASRPSTPTTQ DTTMSVSTAV MSTSTPVCGA QKWTSVCVKV ENTKQSEAKA SHFTAEAKVQ
KGFKLTFYTV SLNATLKDSS DNPEPFIYEW LLKILPGDEM TAFNLNASLA PVRQTRFQLQ
VNSTANVNDT KTQIEHLLQK NYTNGTGSVE PEPNSINVYP IEPGRCPEQT QLMHQGQYLW
PETQARFTAK LQCERDPENQ ATRNCMVNAL TNRAQWDKPD LMSCPTLHKT IADLSNITVT
ANNSEDLAEL IKNLTSDQLF LSHNELIIVF SKMAEILDAG SVTPPLGQTI IDILNKLLGT
ESNLQPFTND ILNVMESLGN RIAFPGNLFS LTSPNLALSV VGVDPRNFSG LAFGVSSFSQ
GVNPQLFLQV FINQGPSSHT IAFISLPSAL ENHFPQHTEL ARSRVQFQFY GKTELFQDSM
KEKSLLTYVI SGSVTNATIR NLRDPVTVTL HHLKPNRLGQ QVQCVFWDLQ KNGGQGGWSP
EGCEVYGTSV NHTTCVCDHL THFGVLLVPS RSPVNSVDNR ILTLITYVGC GLSALFLGIS
LLTYTAFEKL RRDYPSKILM NLSAALLGLN LVFLVDSWLA SFNRRGLCIS VAVILHYFLL
ASFTWMGLEA VHMYFALVKV FNIYVPCYIL KFCSAGWGIP LLVIALVLAI NKDAYGSGLY
AKSLSPSEDS EELFCWVQSD VAFYVSVVAF FLLVLLCNVA VFVVVLLQIR NVKAKQPAGC
RGGLLHDLKS VASITFLLGL TWALAFLAWG PARVPLLYLF SIFNSLQGFF IFVFHCLMKD
SVRKQWRIHL CCGRFRLATT SEWSQSGTKS REKQLAHSPS VKSAKSDKSN STSSTSNESD
SGGRLVSTPD LVYENTLTVP QAHSPSFHDV LRVGPREMEG TYQVCSWLPR ERSY
//
