ID W5NER0_LEPOC Unreviewed; 724 AA.
AC W5NER0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Hepatocyte growth factor {ECO:0000256|ARBA:ARBA00021784, ECO:0000256|PIRNR:PIRNR001152};
DE AltName: Full=Hepatopoietin-A {ECO:0000256|ARBA:ARBA00033078, ECO:0000256|PIRNR:PIRNR001152};
DE AltName: Full=Scatter factor {ECO:0000256|ARBA:ARBA00031997, ECO:0000256|PIRNR:PIRNR001152};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000019119.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000019119.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Potent mitogen for mature parenchymal hepatocyte cells, seems
CC to be a hepatotrophic factor, and acts as a growth factor for a broad
CC spectrum of tissues and cell types. Activating ligand for the receptor
CC tyrosine kinase MET by binding to it and promoting its dimerization.
CC {ECO:0000256|PIRNR:PIRNR001152}.
CC -!- SUBUNIT: Dimer of an alpha chain and a beta chain linked by a disulfide
CC bond. Interacts with SRPX2; the interaction increases HGF mitogenic
CC activity. {ECO:0000256|ARBA:ARBA00025867}.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily.
CC {ECO:0000256|PIRNR:PIRNR001152}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR EMBL; AHAT01029105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NER0; -.
DR STRING; 7918.ENSLOCP00000019119; -.
DR Ensembl; ENSLOCT00000019151.1; ENSLOCP00000019119.1; ENSLOCG00000015530.1.
DR eggNOG; ENOG502QR40; Eukaryota.
DR GeneTree; ENSGT00940000156019; -.
DR InParanoid; W5NER0; -.
DR OMA; CNIKVCE; -.
DR Proteomes; UP000018468; Linkage group LG8.
DR Bgee; ENSLOCG00000015530; Expressed in ovary and 10 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00108; KR; 4.
DR CDD; cd01099; PAN_AP_HGF; 1.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 4.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR027284; Hepatocyte_GF.
DR InterPro; IPR024174; HGF/MST1.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001254; Trypsin_dom.
DR PANTHER; PTHR24261:SF8; HEPATOCYTE GROWTH FACTOR; 1.
DR PANTHER; PTHR24261; PLASMINOGEN-RELATED; 1.
DR Pfam; PF00051; Kringle; 4.
DR Pfam; PF00024; PAN_1; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF500183; Hepatocyte_GF; 1.
DR PIRSF; PIRSF001152; HGF_MST1; 1.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 4.
DR SMART; SM00473; PAN_AP; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF57440; Kringle-like; 4.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00021; KRINGLE_1; 3.
DR PROSITE; PS50070; KRINGLE_2; 4.
DR PROSITE; PS50948; PAN; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00121};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR001152};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121};
KW Pyrrolidone carboxylic acid {ECO:0000256|ARBA:ARBA00023283};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Serine protease homolog {ECO:0000256|PIRNR:PIRNR001152}.
FT DOMAIN 16..116
FT /note="Apple"
FT /evidence="ECO:0000259|PROSITE:PS50948"
FT DOMAIN 120..199
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 203..281
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 294..373
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 382..462
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 488..719
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DISULFID 204..281
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 225..264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 253..276
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 316..355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 344..367
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
SQ SEQUENCE 724 AA; 82443 MW; BE362A2594FCD786 CRC64;
ADKSLPQSFV NLCLICPVVY PVYKSKHPRR NSLHDYRKSD GIHLFKTDSS LLTKSKSLSE
VKCARRCSRN KGLSFICRAF HFDQKTRKCH WLSFDSNTPG VKKEQDFSFD LYEKKDYTRE
CIIGEGSSYK GIKSVTKTGL KCQAWASSVP HDHNFLPSRF KRKDLKENYC RNPNNETSGP
WCYTTDPDIR HQSCEIPQCS EVECMTCNGE NYRGPMDHTE TGKECQRWDL TRPHKHTFHP
KRYPDKGLND NYCRNPDNRL RPWCFTLDPQ TPWEYCNIKV CDVNAKTDID TTTKCFRGQG
EQYRGTVAVT PDGVQCQRWD SQFPHNHSYT PENYKCQDLR ENYCRNPDGA ELPWCFTVDT
KVRTAFCTNI PRCDTEPPAT EECFEGNGEE YRGHLSKTRS GVPCAMWEDN LDRRCITNSA
TNSEIASLEN NFCRNPDKDK HGPWCYTNNS SVPWDYCMIK PCKPSSNVIP TKSDPSQISC
FRHKRIRIVG GAPVKIKEAS WMVSIQKGNS HWCGGSLVRE DWVLTDKQCF SSCVPDLAEY
SVWMGFLHLN DTGREESEKQ VLKISHVVCG PEGSNLALLK LSGNRAALQT ENVRTIPLPV
TGCAIPEHTN CTMYGWGETK GTGHDGIMKV VQLPIVSNER CNAYHRGSLP ITESRLCAGG
KRDEGVCEKD YGGSLVCEEG DFKVVVGVSV HGRGCARSNR PAIFVNVPYY AEWIHKVFKY
YSNL
//
