ID W5NF77_LEPOC Unreviewed; 923 AA.
AC W5NF77;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Scm like with four mbt domains 2 {ECO:0000313|Ensembl:ENSLOCP00000019286.1};
GN Name=SFMBT2 {ECO:0000313|Ensembl:ENSLOCP00000019286.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000019286.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000019286.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AHAT01016168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01016169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NF77; -.
DR STRING; 7918.ENSLOCP00000019286; -.
DR Ensembl; ENSLOCT00000019318.1; ENSLOCP00000019286.1; ENSLOCG00000015669.1.
DR eggNOG; KOG3766; Eukaryota.
DR GeneTree; ENSGT00940000158123; -.
DR InParanoid; W5NF77; -.
DR OMA; NMSEPFH; -.
DR Proteomes; UP000018468; Linkage group LG8.
DR Bgee; ENSLOCG00000015669; Expressed in testis and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd20112; MBT_SFMBT2_rpt1; 1.
DR CDD; cd20114; MBT_SFMBT2_rpt2; 1.
DR CDD; cd20118; MBT_SFMBT2_rpt4; 1.
DR CDD; cd09581; SAM_Scm-like-4MBT1_2; 1.
DR Gene3D; 2.30.30.140; -; 4.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047353; MBT_SFMBT2_rpt1.
DR InterPro; IPR047355; MBT_SFMBT2_rpt4.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037604; Scm-like-4MBT1/2_SAM.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF62; SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 2; 1.
DR Pfam; PF02820; MBT; 4.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 4.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 4.
DR PROSITE; PS51079; MBT; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 36..136
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 144..247
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 257..363
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 371..468
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 850..916
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..694
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..779
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..823
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 103704 MW; 639D9D91255AF6B8 CRC64;
MQKITVPIQE KAQGSTGGNG QQIESDGDSL GEDIDFNWEE YLEETGASAA PHTAFKHVEI
SLQSSFQPGM KLEVANKSNP DTYWVATIIT TCGQLLLLRF SGYGDDRKAD FWVDVMTANL
HPVGWCTQNN KVLMPPEAIK EKYSDWTEFL IQELTGSRTA PANLLEGPLR GKNTVDLIMV
DSLIELQDCQ DPFQYWMVRV IENIGGRLRL RYIGLDCDTH DVWLFYLDFR LRPVGWCQEN
RFSMEPPKEI QGLKAAPEWK EDLDRACTEA AKSPLPLEVF KDHADLCAHS FKAGMKLEMV
DPEEPFHIRP VTVTKVYNDI YFQVTVDNLG AEAALSALVC HAESPGILPV QWCLKNGVNL
THPKGYLNQD FDWADYLKQC GTEAAPDLCF RNTSVSRGFT KNMKLEAVNP MKPSEICVAS
ITKVKGRLMW LHVEGLKKPL PEYIVDVESM DIFPVGWCEA NGYQLTPPHR PVCQKQKKIA
VVQPEKQQLT SESLENLPHN LCPSATLDAD RGATNGKYCC SQIFVNHRCF SGPYLNKGRI
AELPQSVGPG KCTLVLKEVL GMLINAAYKP GRVLRELQLV EDPQWNFQEE TLKAKYKGKT
YRSTIKIVRT SDQVSDFCRK VCLKLQCCPN LFSPALVTDK CPENCSVHTK TKYTYYYGKK
KKVIKPAIGE NLPDSGLAKP ARRRKKRKSI FVQKKRRSST VDYTPAGSPQ CTKYIDAGCL
PEGGMEGCEE ASAQLLMPDS FCWLLQDSEE DEDPEGAEDD TGSEATSSEP RDDHTDASSV
EVVSSRPRRA VTLRRNTDSG GSASTERSRR KRTTRSGSYT EDVKYHPAKR TATKVETFED
EDRLVLDSNP LEWTVADVVR FIKSTDCAPL AKIFQEQDID GQALLLLTLP TVQECMELKL
GPAIKLCHQI ERVKFAFYAQ YAN
//
