ID W5NFA6_LEPOC Unreviewed; 344 AA.
AC W5NFA6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Mitochondrial genome maintenance exonuclease 1 {ECO:0000256|HAMAP-Rule:MF_03030};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_03030};
GN Name=MGME1 {ECO:0000256|HAMAP-Rule:MF_03030};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000019315.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000019315.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease
CC involved in mitochondrial genome maintenance. Has preference for 5'-3'
CC exonuclease activity. Necessary for maintenance of proper 7S DNA
CC levels. Probably involved in mitochondrial DNA (mtDNA) repair.
CC {ECO:0000256|HAMAP-Rule:MF_03030}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03030}.
CC -!- SIMILARITY: Belongs to the MGME1 family. {ECO:0000256|HAMAP-
CC Rule:MF_03030}.
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DR EMBL; AHAT01037501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NFA6; -.
DR STRING; 7918.ENSLOCP00000019315; -.
DR Ensembl; ENSLOCT00000019347.1; ENSLOCP00000019315.1; ENSLOCG00000015691.1.
DR eggNOG; ENOG502QVKE; Eukaryota.
DR GeneTree; ENSGT00390000003349; -.
DR HOGENOM; CLU_068902_0_0_1; -.
DR InParanoid; W5NFA6; -.
DR OMA; FMDTELC; -.
DR Proteomes; UP000018468; Linkage group LG16.
DR Bgee; ENSLOCG00000015691; Expressed in ovary and 13 other cell types or tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0008297; F:single-stranded DNA exodeoxyribonuclease activity; IBA:GO_Central.
DR GO; GO:0043504; P:mitochondrial DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0006264; P:mitochondrial DNA replication; IBA:GO_Central.
DR Gene3D; 3.90.320.10; -; 1.
DR HAMAP; MF_03030; MGME1; 1.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR PANTHER; PTHR31340; MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1; 1.
DR PANTHER; PTHR31340:SF3; MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|HAMAP-Rule:MF_03030};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_03030};
KW Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03030};
KW Nuclease {ECO:0000256|HAMAP-Rule:MF_03030};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 231..299
FT /note="PD-(D/E)XK endonuclease-like"
FT /evidence="ECO:0000259|Pfam:PF12705"
FT ACT_SITE 251
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
FT ACT_SITE 264
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
FT ACT_SITE 266
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
SQ SEQUENCE 344 AA; 38326 MW; 8422699ECDA70116 CRC64;
MRIYRLLSAV WSAKSRSLSV ALVSQGSFSV VRCLSTSCPW NGRRKGSQYD SVDTEKYSSL
VHSVVSSKVS YRTPASLEEE DGQLYGPVVK SKPAAKGTEA KTLKNIVPLL NNAKVLEQQT
VEAELPPPMR IALRKAQGRP AAPSVTRILQ HSMPLEQAFY LERWRKRMIG ELGEEGFKEY
TANLFRQGNQ FHAALEAILM STEVPEEAEA PAGGVCGYVQ SVQHVLADIS GVRAIESAVT
HQTLQYVGLV DCVAQYRGKL CVIDWKTSEK PKPLLHNTFD NPLQVAAYIG AINNDDNYGF
QVEDGLIVVA YKDGSPAHPH FMDSALCLEY WTKWLFRLEE YLEK
//
