ID W5NFP0_LEPOC Unreviewed; 352 AA.
AC W5NFP0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000019449.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000019449.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR EMBL; AHAT01016244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006633437.1; XM_006633374.2.
DR AlphaFoldDB; W5NFP0; -.
DR STRING; 7918.ENSLOCP00000019449; -.
DR Ensembl; ENSLOCT00000019481.1; ENSLOCP00000019449.1; ENSLOCG00000015799.1.
DR GeneID; 102687765; -.
DR KEGG; loc:102687765; -.
DR CTD; 51384; -.
DR eggNOG; KOG3913; Eukaryota.
DR GeneTree; ENSGT00940000157480; -.
DR HOGENOM; CLU_033039_1_0_1; -.
DR InParanoid; W5NFP0; -.
DR OMA; KFERWNC; -.
DR OrthoDB; 2874082at2759; -.
DR Proteomes; UP000018468; Linkage group LG8.
DR Bgee; ENSLOCG00000015799; Expressed in bone element and 6 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0030282; P:bone mineralization; IEA:Ensembl.
DR GO; GO:0060349; P:bone morphogenesis; IEA:Ensembl.
DR GO; GO:1990523; P:bone regeneration; IEA:Ensembl.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0072498; P:embryonic skeletal joint development; IEA:Ensembl.
DR GO; GO:0060218; P:hematopoietic stem cell differentiation; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0030500; P:regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:1902036; P:regulation of hematopoietic stem cell differentiation; IEA:Ensembl.
DR CDD; cd19344; Wnt_Wnt16; 1.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR013304; Wnt16.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF70; PROTEIN WNT-16; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01895; WNT16PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
SQ SEQUENCE 352 AA; 39771 MW; 481AAFD090E90659 CRC64;
MEKSAKFGIH RLCIFLILFF SFFPFHSQGS WMWLGITSLS IPEKMGCGNL PLTNKQKDLC
KRKPYLLPSI KEGARMGISE CQTQFKYERW NCSTTSEFSV FGYELTSGTK ETAFIYAVMA
AGLVHTVTRS CSAGNMTECS CDTTLQGGGS PREGWHWGGC SDDIQYGMWF SRRFLDSATG
NASALLAMNQ HNSEAGRQAV AKMMSTDCRC HGVSGSCAVK TCWKTMSTFE KVGSFLKDRY
ENSIQVLDRS RKKVRRKEKD QRRVPVSKEE LIYVNKSPNY CLEDRKAGIA GTRGRKCNRT
SAGPDGCNLL CCGRGYNTHV VRHVERCECK FVWCCYVRCR RCESMTDMHT CK
//
