ID W5NGI4_LEPOC Unreviewed; 759 AA.
AC W5NGI4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Semaphorin 3C {ECO:0000313|Ensembl:ENSLOCP00000019743.1};
GN Name=SEMA3C {ECO:0000313|Ensembl:ENSLOCP00000019743.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000019743.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000019743.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AHAT01021038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01021039; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006633538.2; XM_006633475.2.
DR AlphaFoldDB; W5NGI4; -.
DR STRING; 7918.ENSLOCP00000019743; -.
DR Ensembl; ENSLOCT00000019775.1; ENSLOCP00000019743.1; ENSLOCG00000016023.1.
DR GeneID; 102690272; -.
DR KEGG; loc:102690272; -.
DR CTD; 10512; -.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000159379; -.
DR HOGENOM; CLU_009051_5_0_1; -.
DR InParanoid; W5NGI4; -.
DR OMA; TVQYGVK; -.
DR OrthoDB; 5342713at2759; -.
DR Proteomes; UP000018468; Linkage group LG8.
DR Bgee; ENSLOCG00000016023; Expressed in muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0045499; F:chemorepellent activity; IBA:GO_Central.
DR GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR CDD; cd05871; Ig_Sema3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF25; SEMAPHORIN-3C; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 40..523
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 602..667
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 759 AA; 86461 MW; D1591844E7B02892 CRC64;
MVLMLLPKPG VMTRSMVLQV MLRIVFHSSW VLSFPQPVPR VYLPFEELQA TQSFQSFSLS
EYPMDYRILL MDEDQDRLYV GCKDHILSMN INNITQGSLK VFWPASSSKI EECKMAGKDP
THGCGNFVRV IQPYNRTHLF ICGTGAFSPV CAYVNRGRRS EEQVFYVDSK AESGKGRCSF
NPNVNTVSVM INEELFSGMY IDFMGTDAAI FRSVTKRNAI RTDQHNSKWL SEPIFIDAQL
IPDGSDPNDA KLYFFFRERL TDNNGNTKHI HTMVARICPN DIGGQRSLVN KWTTFLKARL
VCSVVEEDGT ETFFDELEDI FLLETENPKN LLVFGVFTSS SSVFRGSAVC VYNMADILTV
FNGPFAHKEG PNHQWVAYQG RIPYPRPGTC PGGAFTPNIL TTKDFPDDVV TFIRNHPVMY
NPIYPINKEP LVVRSQADYK YTAVAVDQVI AADGRYHVLF LGTDKGTVQK VIVLPTNRTQ
EKELILEELE VFKNRAPVTT VRISSKKQQL YVSSDYGVTQ MSLHRCDAYG SACADCCLAR
DPYCAWDGKS CSRFYPMGKR RSRRQDIIHG NPLTQCRGFN LKAYRNAAEM VQYGVRNNTT
FLECSPKSPQ ASVKWLIQRE NDRRKEVRLN DRILSTEHGL LLRALQDTDQ GLYYCLATEN
NFKQTVAKIK LKVLSTELVS SLTDKKSLWS WASSLNGLQS HSKGFIEMFS HTEMQTINRY
CKENRHRERL GSLRGDLGKL KPLLDHRKSR NRRNNLPGL
//
