ID W5NHN9_LEPOC Unreviewed; 1356 AA.
AC W5NHN9;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=ASXL transcriptional regulator 2 {ECO:0000313|Ensembl:ENSLOCP00000020148.1};
GN Name=ASXL2 {ECO:0000313|Ensembl:ENSLOCP00000020148.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000020148.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000020148.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the Asx family. {ECO:0000256|ARBA:ARBA00006391}.
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DR EMBL; AHAT01015705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015712; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01015713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSLOCT00000020181.1; ENSLOCP00000020148.1; ENSLOCG00000016319.1.
DR GeneTree; ENSGT00520000055578; -.
DR HOGENOM; CLU_005155_0_0_1; -.
DR Proteomes; UP000018468; Linkage group LG1.
DR Bgee; ENSLOCG00000016319; Expressed in zone of skin and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR026905; ASX-like_PHD.
DR InterPro; IPR024811; ASX/ASX-like.
DR InterPro; IPR028020; ASX_DEUBAD_dom.
DR InterPro; IPR007759; Asxl_HARE-HTH.
DR InterPro; IPR044867; DEUBAD_dom.
DR PANTHER; PTHR13578; ADDITIONAL SEX COMBS LIKE PROTEIN ASXL; 1.
DR PANTHER; PTHR13578:SF11; POLYCOMB GROUP PROTEIN ASXL2-RELATED; 1.
DR Pfam; PF13919; ASXH; 1.
DR Pfam; PF05066; HARE-HTH; 1.
DR Pfam; PF13922; PHD_3; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51913; HTH_HARE; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1..71
FT /note="HTH HARE-type"
FT /evidence="ECO:0000259|PROSITE:PS51913"
FT DOMAIN 260..369
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 72..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 408..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..453
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..501
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1356 AA; 144979 MW; B39FEAD612EFB587 CRC64;
QAAYTVLEKY PNTPMSHKEI LKVIQSEGLK EISGTSPLAC LNAMLHTNSR GEEGIFYKVP
GRMGVYTLKK DVSDSAKDVS DDGSEESSGN HSDSQSTENS NSTNNEDGRK GKWRRKVSSK
LQSQPSSPQS RCQSPSIPAS KLISPSQKHS KKALKQALKQ QQQKNQRKQG GMPTSSNPRL
ILKTVKDMGD QAASKTEWEV KQSDRRSASP QNSTSSSSSS SVKTDLSSSA TAKKVSQRSD
RLSARQLKRT KCAEIDVETP DSILVNTNLR ALINKHTFSV LPPDCQHRLL HLLPEVDRQA
SADGVLKLSS SALNNEFFTS AAQSWKERLA EGEFTPEMRL RIRQEIEKEK KVEQWKERFF
ESYYGQNSGI SIEESRKLTA TLRDTPEPGR QHISPSPSVQ VPPVKSEAKA EPRLEASITE
SKDDERKQPP GTSESLKPEP GNDESKAKAR AVPERLPEAP ASEKTALIQP TQTVVAAQVK
TEETMDTETV KVTKDQQELD GSKTRMSPQT TPKASPDRKE VAMMLTDSPS SVSPMKVPGA
EQMEVALEGL KRKSSTDLEE VLPSPEKRAR VCEAPPKSSS DSMEHTAKPR VPPLKIPVSR
ILTAATVTGQ VSPRAPFTAS LPSTGRTGAR TLADIKAKAQ LARAQRAAAA AAAAAAAAGS
SSGGAVPGPG PGGGGGAQGG ASHTGTAVRE ALTPRAELGG AGGRGTAGGI LPSCPDAKIK
ISPGSVGDSR AQLQQTTTSQ AGASGTTSTL SSLSANTAQA ATPSVRLSTL GNCSNPASLS
NPSTQQSQIS SCNETTGKEQ SKSVPFPIDV VQTVEQKPPA TDGKNTEANK HWKASLEEPS
ALSTMEKASN SNVSLGTQVP TAPLSCIVSG TLSQKASESP VGGGHVTKTS SSIPANNPLV
TQLLQGKEVP LEQILPKPHT KIDVKPIILP SGDKGKISHV TTETDTVVSG DDHSRLGTDA
FEKARQLLPN QLISTRTGGM ELAQHHREML NKATQEQILQ TLMQRAQTQQ FITGSQLLQH
EICHFGYPAE CSRSQSFAMG FMGRKRMSKP AMSGHYLLNI STYGRGSESY KRAHLSINAP
LANLKKECID GEITPDEGEE PFKSPNDYVK GQPDLTGIKK EHQGLGDGSY TATSPSHTKS
SALLDHNHSH KIKRESPSLG QVPDREEDSV LTDSKDAAAT AKEINRVVQS HKVYPEVGNN
PHSNSEPYRL PKHTGMDRHH WQAAHHHQQK NYESHGPVVG HIYGGTINMS TSHALNHSSA
GSGSSPGYSP VSSSSGGVMS FSVTVTTIPA NHPLDHANHG EAGPVQAFAE SSSMDDSPSK
CYCRLKAMIM CKGCGAFCHD DCIGPSKLCV SCLVVR
//
