ID   W5NI03_LEPOC            Unreviewed;       473 AA.
AC   W5NI03;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   27-MAR-2024, entry version 44.
DE   SubName: Full=Sushi domain containing 4 {ECO:0000313|Ensembl:ENSLOCP00000020262.1};
OS   Lepisosteus oculatus (Spotted gar).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC   Lepisosteus.
OX   NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000020262.1, ECO:0000313|Proteomes:UP000018468};
RN   [1] {ECO:0000313|Proteomes:UP000018468}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT   "The Draft Genome of Lepisosteus oculatus.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLOCP00000020262.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR   EMBL; AHAT01008948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01008949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AHAT01008950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5NI03; -.
DR   STRING; 7918.ENSLOCP00000020262; -.
DR   Ensembl; ENSLOCT00000020296.1; ENSLOCP00000020262.1; ENSLOCG00000016408.1.
DR   eggNOG; ENOG502QU1F; Eukaryota.
DR   GeneTree; ENSGT00940000160410; -.
DR   HOGENOM; CLU_044351_1_0_1; -.
DR   InParanoid; W5NI03; -.
DR   OMA; IIACHEG; -.
DR   Proteomes; UP000018468; Linkage group LG1.
DR   Bgee; ENSLOCG00000016408; Expressed in heart and 10 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043009; P:chordate embryonic development; IEA:Ensembl.
DR   GO; GO:0045957; P:negative regulation of complement activation, alternative pathway; IBA:GO_Central.
DR   GO; GO:0045959; P:negative regulation of complement activation, classical pathway; IBA:GO_Central.
DR   CDD; cd00033; CCP; 4.
DR   Gene3D; 2.10.70.10; Complement Module, domain 1; 4.
DR   InterPro; IPR042985; SUSD4.
DR   InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR   InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR   PANTHER; PTHR47007; SUSHI DOMAIN-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR47007:SF1; SUSHI DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF00084; Sushi; 4.
DR   SMART; SM00032; CCP; 4.
DR   SUPFAM; SSF57535; Complement control module/SCR domain; 4.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR   PROSITE; PS50923; SUSHI; 3.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW   Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        300..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          34..98
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DOMAIN          157..218
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DOMAIN          220..283
FT                   /note="Sushi"
FT                   /evidence="ECO:0000259|PROSITE:PS50923"
FT   DISULFID        189..216
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ   SEQUENCE   473 AA;  52665 MW;  8DADCF19F4F729F7 CRC64;
     MQHWNAKSIP YQSHSVSWQS TLAACAAHLQ IKKQFCSDPS FPEHGNRTPS SGVFFENAVA
     HFYCLAGYRL KGPSKTVCVR LHNESMGWKP SQKPLCLPED CLVPYIEDAD IHNKTYRPGD
     KLIIRCHEGF QIRYPDMDNM VSVCQDDGTW DSLPICQGCL RPVVPPHSYM NISEIEFSVP
     VGTVVRYQCF PGYKLDGSEV LECMYNLIWS DIPPRCLDVE VCPLPPMVEH GDYICHPNPC
     DRYIHGTVVE FYCDPGYSLA NDYRYITCQY GQWFPHIQVY CVKSAEPSWP NSQESLLTTW
     KVFAFTATSV LLALLLVILG KVFQFRCKTH CQLRDGQQGA SSPNFVVVDG IPVLLPSYDE
     AVSSSNVLPP SFPPPAGQGE SLHIEEQGPP AYPGHVESIS AVHPETSEYE TCESLTDSFE
     HLQSICPSST CPGGLNNTSE RANVMTSTAD TASTSPSIDI ADEIPLVEEE EGY
//