ID W5NI57_LEPOC Unreviewed; 449 AA.
AC W5NI57;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=ETS variant transcription factor 6 {ECO:0000313|Ensembl:ENSLOCP00000020316.1};
GN Name=ETV6 {ECO:0000313|Ensembl:ENSLOCP00000020316.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000020316.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000020316.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR EMBL; AHAT01033549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01033550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NI57; -.
DR STRING; 7918.ENSLOCP00000020316; -.
DR Ensembl; ENSLOCT00000020350.1; ENSLOCP00000020316.1; ENSLOCG00000016444.1.
DR eggNOG; KOG3804; Eukaryota.
DR GeneTree; ENSGT00940000159508; -.
DR InParanoid; W5NI57; -.
DR OMA; HREDMAY; -.
DR Proteomes; UP000018468; Linkage group LG8.
DR Bgee; ENSLOCG00000016444; Expressed in pharyngeal gill and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd08535; SAM_PNT-Tel_Yan; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF19; TRANSCRIPTION FACTOR ETV6; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 40..124
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 335..418
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 21..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 145..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 52466 MW; 3514420634E553C3 CRC64;
FIQSSEAIIF QQENLSFSPL TSPLPSSTSS AVHVPTSRQA SRMEEEPTRL PAHLRLQPVY
WSRDDVSQWL KWAEKEFSLH PINNNTFEMN GKALLLLTKE DFRYRSPHSG DVLYELLQHI
LKQRKSHSFY PSFFYPGNSF QTQPEAAVQH SKLEETVRRT PRGTEGLHHN PPTIELRHRP
RSPRLNNQDL SPDSQRSPLD NASRHLSPED RLRPASQPQE NNHTASLEEP YQLSVSPEQN
NSHCPTPTEG QRSGSPYQDN PRVIQLVPSA IMHPLIINPR QTLDLKHSRS SDNGWEGKPM
NLTHREDLLY RNHIMMPVSP PEEKPLPIGR IADCRLLWDY VYQLLSDSRY ENYIRWEDKE
TKVFRIVDPN GLARLWGNHK TKNRTNMTYE KMSRALRHYY KLNIIRKEPG QRLLFRFMKT
PDEIMSGQTD RLEHLESDLD DQMYVKEEC
//
