ID W5NIV6_LEPOC Unreviewed; 492 AA.
AC W5NIV6;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=[histone H3]-lysine(4) N-trimethyltransferase {ECO:0000256|ARBA:ARBA00012182};
DE EC=2.1.1.354 {ECO:0000256|ARBA:ARBA00012182};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000020565.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000020565.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) +
CC N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60260, Rhea:RHEA-COMP:15537, Rhea:RHEA-
CC COMP:15547, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.354;
CC Evidence={ECO:0000256|ARBA:ARBA00000944};
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DR EMBL; AHAT01027742; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01027743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01027744; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01027745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01027746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01027747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01027748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NIV6; -.
DR STRING; 7918.ENSLOCP00000020565; -.
DR Ensembl; ENSLOCT00000020600.1; ENSLOCP00000020565.1; ENSLOCG00000016648.1.
DR eggNOG; KOG2084; Eukaryota.
DR GeneTree; ENSGT00940000156766; -.
DR HOGENOM; CLU_018406_2_0_1; -.
DR InParanoid; W5NIV6; -.
DR OMA; LHMKLGK; -.
DR Proteomes; UP000018468; Linkage group LG1.
DR Bgee; ENSLOCG00000016648; Expressed in pharyngeal gill and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd19203; SET_SMYD3; 1.
DR Gene3D; 1.10.220.160; -; 1.
DR Gene3D; 1.25.40.970; -; 1.
DR Gene3D; 6.10.140.2220; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044420; SMYD3_SET.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR002893; Znf_MYND.
DR PANTHER; PTHR12197; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD; 1.
DR PANTHER; PTHR12197:SF288; HISTONE-LYSINE N-METHYLTRANSFERASE SMYD3; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF01753; zf-MYND; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
DR PROSITE; PS50865; ZF_MYND_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00134}.
FT DOMAIN 67..303
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 112..150
FT /note="MYND-type"
FT /evidence="ECO:0000259|PROSITE:PS50865"
SQ SEQUENCE 492 AA; 56095 MW; 7438A96C0EC65C20 CRC64;
MYSIFRSLAV LDRRNRSYGL KKKIPRSRDN VCSLCGLSGS RKFIPARAPV PGSLFSPIGA
ARAVMARRLE RFCSPGKGHG LRALAPLRPG ELLYTAEPFA CTVSTRGRGS TCESCFSRKE
KLLRCSQCKI ARYCDASCQK AAWSEHKREC KCLRSFHPRI PTDSVRLAGR IVFKLLNYSS
CPSEELFSLL EHESHIKEMS EEKKEGLGHL ATMLQLYLKE EVGDLSQLPP GLDIIHLFAI
MTCNCFTISD GELQEIGVGL YPSMSLLNHD CDPNCVIVFQ GRRLFLRAIR EIRPAEELTV
SYIDVLVPAQ ERRTQLQNQY CFVCECQQCD TRNKDEDMLA GNEKAWKSIK DATPGMEKLQ
SQHQWEQVLS LCQTLVDNNQ GILPDTNIYL LKMLDYTMDA CINLRKWDKA LFFGTRTLQP
YRMYYQGFHP ALGVQLMRLG KLQYYMERFC EALDTLKQAY EVMKVTHGVD HPLTTDLQQM
LGECQAEMDR TT
//
