ID W5NJR3_LEPOC Unreviewed; 1977 AA.
AC W5NJR3;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Ral GTPase activating protein catalytic alpha subunit 2 {ECO:0000313|Ensembl:ENSLOCP00000020872.1};
GN Name=RALGAPA2 {ECO:0000313|Ensembl:ENSLOCP00000020872.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000020872.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000020872.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AHAT01011823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01011824; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01011825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01011826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01011827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015209777.1; XM_015354291.1.
DR Ensembl; ENSLOCT00000020908.1; ENSLOCP00000020872.1; ENSLOCG00000016884.1.
DR GeneID; 102690377; -.
DR CTD; 57186; -.
DR GeneTree; ENSGT00950000183139; -.
DR HOGENOM; CLU_001676_0_0_1; -.
DR OrthoDB; 21929at2759; -.
DR Proteomes; UP000018468; Linkage group LG1.
DR Bgee; ENSLOCG00000016884; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF2; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-2; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468}.
FT DOMAIN 1738..1946
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 342..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..846
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 878..894
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1977 AA; 222911 MW; AFD74C85BB918F1F CRC64;
MFSRRSHGDV KKSSQKVLDP KKDVLTRLKH LRSLLDILER GELKAFFENN CSQIYFIFYE
NFITLESNLK QKGNKSQREE LDSILFLLEK ILQLLPEKIY NRWQFHSIGT ILKKLLHTGN
SFKIRSEGIR LFLLWLQALQ NNCSEEQLLI FACLVPGFPA VPSSRGPCTL DTIIYNPFSN
PPDAKVVPEE ITPLVPAVAG EKVADDQTCF LLQTLLKYMV IQASSLEWRN RENQDTGFRF
LFALFKKYYL PHLFPCFTKL TNLYKPLLDI PHLRPKPLYV PVTRNNESTY CTRDQYLAPR
VAFIKWLVTF FLEKKYVTTA VQNSKNGVEV LPKIIQTVTA GSTSQEKNAE AESNCPVEQD
KNHSNSSTLS DRRHSNSSLC SIEEEHRSVY DMVHSILLST RDNVNFVNEV FHQAFLLPSC
EASATRKVIK VYRKWILQEK PMFMTEPEKT KQEEEGDDIP VHLLISETDS KQATESSGHK
RTSSWGRTYS FSSAISRGCI SEEENRDVKA GIQSVLQVFL TNSANVFLLE PCHDVPKLME
DQVDVCKGVL SIYRRMIMEH TMNQKTWEQM LQVLLRITEA VMRRSQENQR KDPFAESLAC
LLFRTIIVAW VRANLSVFVS RELWDELLSV LSSLTDWEEL INEWANIMDS LTTVLVRSVY
GLDMSNLPLD KLSEQKEKIQ RGRGVIQDAQ KAAAVGRSFS LSWKNQADAQ EPMRFRSATT
SGAPGVEKAR NNVRQKATAK RSQSISNCVQ LYEALPATKS VPMLLHTVSS FLPGISSSSC
SQRLSEVDEC PPADGGAEGE PAELGEQGLP RSSSTSDIAR QLSETLQGQK REYSPNASSS
DMRTCGLENA SRVRRESEPP VILVRRSSSP PDVEYPGDSH LHSGKTRLRE KSESVSSETS
NGYINENDVS LMSWQAFEEE QDSQSPSDVT IDPDTQRSLL QLSPTDALTG SDCALPPHSA
PSSHPQLPSA SPALLAHPDC KDCPPLLEET VHQSVLHMPE DLDSSECLAD DISIIAGGSL
TGWHPDSAAV LWRRVLGILG DVNCIRCPKI HAKVFCYLYE LWHKLAKIRD NQGISVDNQS
SPPRPVLIPP LRMFASWLFK ATALPPQFKE GQLQAYRLIC EMMTKHQDVL PNSDFLVHFY
HVMHKAFTSE DQDVLNTVIR HCSPRFFFLG LPGFTMLVGD FITAAARILS TETLEAPRIE
AQTLLGSLVC FPNLYQQMPL LQTVPGTTDI IVGNEEIKDY LINILLTIAR NEPSEGARCI
AICSLGVWIC EELVQQTNHP NVRDAINVIG VTLKFSNKVV AHVACDVFQL LICHWQNLQR
YEYSLPKKIT EIFVATIAFL LPNAEHSTVE ADKKLMVSLL LCLLDWCMAI PLNTLLEPIT
MPVLEDSSQK APLLDYIYRV LHCCVYGSNL HTQQSHYLLS LADLSATDYD PFLLLGNVKN
CEPQPSHSSV DFGNLLTVAE EKKRRNMELI PLTARMIMTH LVNHLGHYPL SGGPAVLHSL
INENHDNHYV ESSELSSEVF KSPNLQLFVF NESTLVSYLQ IPAEKAGAGE PQMASSEVRV
IVRDISGKYS WDGRVLYRPL DGPMSGQNND YIPTMHCGST WSSDKTHPAN WDCPDTEEGD
DVLDKLLEDL GHSSPECLPQ PQLKLNEPAS SPFGMSLEQE NAITETILRQ TNQEEENVKK
CSNDLRMKVA SQKEPTHQEP KAPFYFCRLL LNDLGMNSWD RRKSFHLLKK NSKLLRELKN
LDSRQCRETH KIAVFYIGDG QEDKCSILSN TEGSQAYEDF VSGLGWEVDL ATHCGFMGGL
QRNGSTGHTA PYFATSTVEV IFHVSTRMPS DSDDSLTKKL RHLGNDEVHI VWSEHNRDYR
RGIIPTDFGD VLIIIYPVKN HMFFIQIMKK PQVPFFGPLF DGAIVTGTLL PSLVRATCIN
ASRAVKSRLT LYQSFYEERA LYLEAIVQNH REVMTFEDFA SQVFTPSPSY YSLSGTD
//
