ID W5NK18_LEPOC Unreviewed; 669 AA.
AC W5NK18;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Poly (ADP-ribose) polymerase family, member 12a {ECO:0000313|Ensembl:ENSLOCP00000020977.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000020977.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000020977.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
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DR EMBL; AHAT01034293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01034294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01034295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01034296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AHAT01034297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NK18; -.
DR STRING; 7918.ENSLOCP00000020977; -.
DR Ensembl; ENSLOCT00000021013.1; ENSLOCP00000020977.1; ENSLOCG00000016964.1.
DR eggNOG; ENOG502QSC4; Eukaryota.
DR GeneTree; ENSGT00940000154649; -.
DR HOGENOM; CLU_014825_2_1_1; -.
DR InParanoid; W5NK18; -.
DR OMA; ADMNEIC; -.
DR Proteomes; UP000018468; Linkage group LG8.
DR Bgee; ENSLOCG00000016964; Expressed in intestine and 11 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IBA:GO_Central.
DR GO; GO:1990404; F:NAD+-protein ADP-ribosyltransferase activity; IBA:GO_Central.
DR CDD; cd01439; TCCD_inducible_PARP_like; 1.
DR Gene3D; 3.30.1370.210; -; 1.
DR Gene3D; 3.30.720.50; -; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR037197; WWE_dom_sf.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR45740:SF13; POLY (ADP-RIBOSE) POLYMERASE FAMILY, MEMBER 12B; 1.
DR PANTHER; PTHR45740; POLY [ADP-RIBOSE] POLYMERASE; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF02825; WWE; 1.
DR SMART; SM00356; ZnF_C3H1; 3.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF117839; WWE domain; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS50918; WWE; 1.
DR PROSITE; PS50103; ZF_C3H1; 3.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT DOMAIN 96..121
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 182..204
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 267..293
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 359..447
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 477..669
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT ZN_FING 96..121
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 182..204
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 267..293
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
SQ SEQUENCE 669 AA; 76693 MW; 7357255BAE9E3ECE CRC64;
KMSGLVISNC ATKTLCRNQG CLEYRLLKGV VCQSCNVGDR RLFDVLSDSS RFVIVQGREE
NIPGCDLSPD SIIVAKTRLR LCKSYPECNT CEDLHLCRYF VCGHCRYGQG RNKCRNSHDI
HSDHNGAILR AHFLQDLDEA ELFQLLLQND SYLLPEICLH YNKGSGPYGS CTFKERCTNL
HVCQHYIQGD CKFGGNCKRF HSFDMNARNI LSGRGLSAEK IHILPAIYKN KYRIDSSAQT
PAKALTVSIG KKERLRHVST SSVNEVDRKE ICLFFIRKHC SFKDKCVRVH YHLPYKWEIL
DSDGTTWKYL PNMEEIEKAY CDPENSTRSS YSSLGSPAVN FLTMTCGPAE VRRLSTASSV
TKPPHVILTT EWVWYWKNEF GKWIEYGCPE DEQSESSSVT SSVLEKVYLA DNESDVPFIT
GGQQYILSFK DMYQQDRKNT AKREVRRRPR FVSAQDVERK IKRSVSLMTP GSADVSIPSH
WVQVPLLDFT HKLVHQSKSG EEYRQIETLF RRSMATSTIH KIQRIQNLYL WNVFQWQKDQ
MMKRNGGKTV NECFLFHGTE KSLIKAICEQ NFDRGISGAH NAYGIGNYFS RDASYFHNNS
KPTTGSRIMF VARVLVGDFS QGNSNYLHPP LKEGNSVFYD SCVDSTSNPS VFVIFEKHQI
YPEYLIEYS
//
