ID W5NLM4_LEPOC Unreviewed; 216 AA.
AC W5NLM4;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Claudin-3-like {ECO:0000313|Ensembl:ENSLOCP00000021533.1};
GN Name=CLDN3 {ECO:0000313|Ensembl:ENSLOCP00000021533.1};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000021533.1, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000021533.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}.
CC -!- SIMILARITY: Belongs to the claudin family.
CC {ECO:0000256|ARBA:ARBA00008295}.
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DR EMBL; AHAT01005728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_015223339.1; XM_015367853.1.
DR AlphaFoldDB; W5NLM4; -.
DR STRING; 7918.ENSLOCP00000021533; -.
DR Ensembl; ENSLOCT00000021570.1; ENSLOCP00000021533.1; ENSLOCG00000017428.1.
DR GeneID; 102699254; -.
DR KEGG; loc:102699254; -.
DR CTD; 81582; -.
DR eggNOG; ENOG502QRZ8; Eukaryota.
DR GeneTree; ENSGT00940000162095; -.
DR HOGENOM; CLU_076370_1_2_1; -.
DR InParanoid; W5NLM4; -.
DR OMA; RYGPPSK; -.
DR OrthoDB; 4040914at2759; -.
DR Proteomes; UP000018468; Linkage group LG22.
DR Bgee; ENSLOCG00000017428; Expressed in intestine and 10 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR006187; Claudin.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR PANTHER; PTHR12002; CLAUDIN; 1.
DR PANTHER; PTHR12002:SF112; CLAUDIN-3; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01077; CLAUDIN.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 34..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 216 AA; 23366 MW; E23A3BC32399DEE7 CRC64;
MASLGLEILG VALAVFGWIG SILACALPMW RVSAFIGINI MTAQIFWEGI WMSCVVQSTG
QMQCKVYDSM LALPQDLQAA RALEVISIIL GFLGILVSIV GAKCTSCIED EVTKSRVMIT
TGVTFNIASI MQLIPVSWSA NTIIREFYSP IIPEAQKREI GASLYIGWAA AALLLLGGSI
LCCSCPPRET KYTPPRLAYS TARSGVPSGY DRKDYV
//
