ID W5NNT5_LEPOC Unreviewed; 356 AA.
AC W5NNT5;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 11-DEC-2019, entry version 36.
DE SubName: Full=Potassium voltage-gated channel subfamily J member 15 {ECO:0000313|Ensembl:ENSLOCP00000022294};
GN Name=KCNJ15 {ECO:0000313|Ensembl:ENSLOCP00000022294};
OS Lepisosteus oculatus (Spotted gar).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Holostei; Semionotiformes; Lepisosteidae;
OC Lepisosteus.
OX NCBI_TaxID=7918 {ECO:0000313|Ensembl:ENSLOCP00000022294, ECO:0000313|Proteomes:UP000018468};
RN [1] {ECO:0000313|Ensembl:ENSLOCP00000022294, ECO:0000313|Proteomes:UP000018468}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lander E.S., Lindblad-Toh K.;
RT "The Draft Genome of Lepisosteus oculatus.";
RL Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLOCP00000022294}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (FEB-2014) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC ECO:0000256|SAAS:SAAS00549381}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AHAT01003126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006628108.1; XM_006628045.2.
DR RefSeq; XP_015196674.1; XM_015341188.1.
DR STRING; 7918.ENSLOCP00000022294; -.
DR Ensembl; ENSLOCT00000022335; ENSLOCP00000022294; ENSLOCG00000018193.
DR GeneID; 102689514; -.
DR CTD; 3772; -.
DR GeneTree; ENSGT00980000198471; -.
DR OMA; YLHDIWT; -.
DR OrthoDB; 956263at2759; -.
DR Proteomes; UP000018468; Linkage group LG3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1400; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR041647; IRK_C.
DR InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR InterPro; IPR003270; K_chnl_inward-rec_Kir1.3.
DR InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR InterPro; IPR040445; Kir_TM.
DR PANTHER; PTHR11767; PTHR11767; 1.
DR PANTHER; PTHR11767:SF20; PTHR11767:SF20; 1.
DR Pfam; PF01007; IRK; 1.
DR Pfam; PF17655; IRK_C; 1.
DR PIRSF; PIRSF005465; GIRK_kir; 1.
DR PRINTS; PR01323; KIR13CHANNEL.
DR PRINTS; PR01320; KIRCHANNEL.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434609};
KW Ion transport {ECO:0000256|RuleBase:RU003822,
KW ECO:0000256|SAAS:SAAS00434639};
KW Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434575};
KW Potassium transport {ECO:0000256|RuleBase:RU003822,
KW ECO:0000256|SAAS:SAAS00434641};
KW Reference proteome {ECO:0000313|Proteomes:UP000018468};
KW Transmembrane {ECO:0000256|RuleBase:RU003822,
KW ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00036755};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW ECO:0000256|SAAS:SAAS00048561}.
FT TRANSMEM 64..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..168
FT /note="IRK"
FT /evidence="ECO:0000259|Pfam:PF01007"
FT DOMAIN 175..342
FT /note="IRK_C"
FT /evidence="ECO:0000259|Pfam:PF17655"
FT SITE 154
FT /note="Role in the control of polyamine-mediated channel
FT gating and in the blocking by intracellular magnesium"
FT /evidence="ECO:0000256|PIRSR:PIRSR005465-1"
SQ SEQUENCE 356 AA; 40445 MW; 726F0A3F2E728257 CRC64;
MSPPETSVEP FLSKSAGKAS WRKRRVVSKD GHNIVKVDNI EGMVKLYLHD IWTTVVDIKW
RYKLTLFSAT FVTTWFIFGI VFYLIGKGHG DMSVPEIPSN HTPCVMNVKT LTGAFLFSLE
SQTTIGYGFR YISEECPLAI FTLVAQLVIT CLAEIFVTGA FLAKLARPKK RAETIKFSHY
AVISKYEGKL CLMVRVANMR KSLLIQCRLS GKLLHCYETK EGEKIPLSQA SVNFQVDSNT
ESPFLILPLT FYHVIDEESP LRGLTAEDLR KKDFELVLIL NAITEATASS CQSRTSYVPD
EILWGYEFLP MLFMSPRGKY VADFSQYDGV RRCGDPSLFC NDLEKLKLEE EYRKEA
//
