GenomeNet

Database: UniProt
Entry: W5NPU8_SHEEP
LinkDB: W5NPU8_SHEEP
Original site: W5NPU8_SHEEP 
ID   W5NPU8_SHEEP            Unreviewed;       405 AA.
AC   W5NPU8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   16-OCT-2019, entry version 40.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOARP00000000188};
GN   Name=KCNJ16 {ECO:0000313|Ensembl:ENSOARP00000000188};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000188, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000000188, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000188,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000000188}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AMGL01019562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004013196.1; XM_004013147.3.
DR   RefSeq; XP_012041990.1; XM_012186600.2.
DR   RefSeq; XP_012041991.1; XM_012186601.1.
DR   RefSeq; XP_012041995.1; XM_012186605.2.
DR   RefSeq; XP_012041996.1; XM_012186606.1.
DR   RefSeq; XP_012041999.1; XM_012186609.1.
DR   RefSeq; XP_012042000.1; XM_012186610.2.
DR   RefSeq; XP_014954471.1; XM_015098985.1.
DR   RefSeq; XP_014954472.1; XM_015098986.1.
DR   STRING; 9940.ENSOARP00000000188; -.
DR   Ensembl; ENSOART00000000214; ENSOARP00000000188; ENSOARG00000000206.
DR   GeneTree; ENSGT00970000193347; -.
DR   OMA; SSYPIVN; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000002356; Chromosome 11.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR008061; K_chnl_inward-rec_Kir5.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF24; PTHR11767:SF24; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01678; KIR5CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     74     95       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       38    151       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      168    334       IRK_C. {ECO:0000259|Pfam:PF17655}.
SQ   SEQUENCE   405 AA;  45879 MW;  57AF113990D6E815 CRC64;
     MSYYGSSYPI VSVDPKRPGY APEHLLAEKR GARRRLLHKD GSCNVYFRHI SGEWGSYVAD
     IFTTLVDTKW RHMFVIFSLS YVLSWLTFGL VFWLIAFQHG DLQDGGPDAA PCVDNVRSFT
     AAFLFSLETQ TTIGYGYLRP VRRCVTTPFI IGAALAKMAT ARKRAQTIRF SSFALVGMRD
     GRLCLMWRIG DFRPNHVVEG TVRAQLLRYA EDGEGRVTML FKDLRLLNDQ IILVTPVTVV
     HEIDRDSPLY ALDRKAVARD NFEILVTFIY TGDSTGTSHQ SRSSYVPREI LWGHRFHDVL
     EVKRKYYKVN CLQFEGSAEV YAPFCSAKQL DWKDQQLHGV EKAPPARASA PPDAKVRRRS
     FSAVAIVSSS ENPEETTPSA PEECKEAPYQ KALLTLNRIS VESQM
//
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