ID W5NQK0_SHEEP Unreviewed; 1053 AA.
AC W5NQK0;
DT 16-APR-2014, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRID1 {ECO:0000313|Ensembl:ENSOARP00000000440.1};
OS Ovis aries (Sheep).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000440.1, ECO:0000313|Proteomes:UP000002356};
RN [1] {ECO:0000313|Ensembl:ENSOARP00000000440.1, ECO:0000313|Proteomes:UP000002356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000440.1,
RC ECO:0000313|Proteomes:UP000002356};
RX PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA Wang W., Xun X.;
RT "The sheep genome reference sequence: a work in progress.";
RL Anim. Genet. 41:449-453(2010).
RN [2] {ECO:0000313|Ensembl:ENSOARP00000000440.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR EMBL; AMGL01071889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMGL01071898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; W5NQK0; -.
DR SMR; W5NQK0; -.
DR STRING; 9940.ENSOARP00000000440; -.
DR PaxDb; 9940-ENSOARP00000000440; -.
DR Ensembl; ENSOART00000000468.1; ENSOARP00000000440.1; ENSOARG00000000438.1.
DR eggNOG; KOG1052; Eukaryota.
DR HOGENOM; CLU_007257_9_0_1; -.
DR OMA; QIFPLAR; -.
DR Proteomes; UP000002356; Chromosome 25.
DR Bgee; ENSOARG00000000438; Expressed in thyroid gland and 38 other cell types or tissues.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004970; F:ionotropic glutamate receptor activity; IEA:InterPro.
DR CDD; cd06392; PBP1_iGluR_delta_1; 1.
DR CDD; cd13730; PBP2_iGluR_delta_1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF108; GLUTAMATE RECEPTOR IONOTROPIC, DELTA-1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU367118};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT CHAIN 20..1053
FT /note="Glutamate receptor"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT /id="PRO_5027165555"
FT TRANSMEM 607..630
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 681..702
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 875..899
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 482..851
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 492..554
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 35..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..1011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 116501 MW; FC459D044F5D1973 CRC64;
MDHVHMCLLW TMLAYLGWCI FPTSKLSYQA ETPAQNSHHP AARSPASAVI GGGGKGEPIS
RPGVDPSSPP GAIFEENAAK DDRVFQLAVS DLSLNDDILQ SEKITYSIKV IEANNPFQAV
QEACDLMTQG ILALVTSTGC ASANALQSLT DAMHIPHLFV QRNPGGSPRT ACHLNPSPDG
EAYTLASRPP VRLNDVMLRL VTELRWQKFV MFYDSEYDIR GLQSFLDQAS RLGLDVSLQK
VDKNISHVFT SLFTTMKTEE LNRYRDTLRR AILLLSPQGA HSFINEAVET NLASKDSHWV
FVNEEISDPE ILDLVHSALG RMTVVRQIFP SAKDNQKCMR NNHRISSLLC DPQEGYLQML
QISNLYLYDS VLMLANAFHR KLEDRKWHSM ASLNCIRKST KPWNGGRSML DTIKKGHITG
LTGVMEFRED SSNPYVQFEI LGTTYSETFG KDMRKLATWD SEKGLNGSLQ ERPMGSRLQG
LTLKVVTVLE EPFVMVAENI LGQPKRYKGF SIDVLDALAK ALGFKYEIYQ APDGRYGHQL
HNTSWNGMIG ELISKRADLA ISAITITPER ESVVDFSKRY LDYSVGILIK KPEEKISIFS
LFAPFDFAVW ACIAAAIPVV GVLIFVLNRI QAVRAQSAAQ PRPSASATLH SAIWIVYGAF
VQQGGESSVN SMAMRIVMGS WWLFTLIVCS SYTANLAAFL TVSRMDNPIR TFQDLSKQVE
MSYGTVRDSA VYEYFRAKGT NPLEQDSTFA ELWRTISKNG GADNCVSSPS EGIRKAKKGN
YAFLWDVAVV EYAALTDDDC SVTVIANSVS SKGYGIALQH GSPYRDLFSQ RILELQDTGD
LDVLKQKWWP HTGRCDLTSH TSAQADGKSL KLHSFAGVFC ILAIGLLLAC LVAALELWWN
SNRCHQETPK EDKEVNLEQV HRRMNSLMDE DIAHKQISPA SIELSALEMG GLAPSQALEP
TREYQNTQLS VSTFLPEQSS HGTSRTLSSG PSSNLPLPLS SSATMPSMQC KHRSPNGGLF
RQSPVKTPIP MSFQPVPGGV LPEALDTSHG TSI
//