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Database: UniProt
Entry: W5NQK0_SHEEP
LinkDB: W5NQK0_SHEEP
Original site: W5NQK0_SHEEP 
ID   W5NQK0_SHEEP            Unreviewed;      1053 AA.
AC   W5NQK0;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN   Name=GRID1 {ECO:0000313|Ensembl:ENSOARP00000000440.1};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000000440.1, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000000440.1, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000000440.1,
RC   ECO:0000313|Proteomes:UP000002356};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C., Wang J.,
RA   Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000000440.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC       channel in the central nervous system and plays an important role in
CC       excitatory synaptic transmission. L-glutamate acts as an excitatory
CC       neurotransmitter at many synapses in the central nervous system.
CC       {ECO:0000256|RuleBase:RU367118}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC       Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC       family. {ECO:0000256|RuleBase:RU367118}.
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DR   EMBL; AMGL01071889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071890; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMGL01071898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; W5NQK0; -.
DR   SMR; W5NQK0; -.
DR   STRING; 9940.ENSOARP00000000440; -.
DR   PaxDb; 9940-ENSOARP00000000440; -.
DR   Ensembl; ENSOART00000000468.1; ENSOARP00000000440.1; ENSOARG00000000438.1.
DR   eggNOG; KOG1052; Eukaryota.
DR   HOGENOM; CLU_007257_9_0_1; -.
DR   OMA; QIFPLAR; -.
DR   Proteomes; UP000002356; Chromosome 25.
DR   Bgee; ENSOARG00000000438; Expressed in thyroid gland and 38 other cell types or tissues.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004970; F:ionotropic glutamate receptor activity; IEA:InterPro.
DR   CDD; cd06392; PBP1_iGluR_delta_1; 1.
DR   CDD; cd13730; PBP2_iGluR_delta_1; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR019594; Glu/Gly-bd.
DR   InterPro; IPR001508; Iono_Glu_rcpt_met.
DR   InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR   InterPro; IPR001320; Iontro_rcpt_C.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR18966:SF108; GLUTAMATE RECEPTOR IONOTROPIC, DELTA-1; 1.
DR   PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00060; Lig_chan; 1.
DR   Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR   PRINTS; PR00177; NMDARECEPTOR.
DR   SMART; SM00918; Lig_chan-Glu_bd; 1.
DR   SMART; SM00079; PBPe; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU367118};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|RuleBase:RU367118};
KW   Ion transport {ECO:0000256|RuleBase:RU367118};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW   ECO:0000256|RuleBase:RU367118};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW   Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW   ECO:0000256|RuleBase:RU367118};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU367118};
KW   Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU367118};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU367118};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|RuleBase:RU367118"
FT   CHAIN           20..1053
FT                   /note="Glutamate receptor"
FT                   /evidence="ECO:0000256|RuleBase:RU367118"
FT                   /id="PRO_5027165555"
FT   TRANSMEM        607..630
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367118"
FT   TRANSMEM        681..702
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367118"
FT   TRANSMEM        875..899
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367118"
FT   DOMAIN          482..851
FT                   /note="Ionotropic glutamate receptor C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00079"
FT   DOMAIN          492..554
FT                   /note="Ionotropic glutamate receptor L-glutamate and
FT                   glycine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00918"
FT   REGION          35..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          975..1014
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        975..1011
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1053 AA;  116501 MW;  FC459D044F5D1973 CRC64;
     MDHVHMCLLW TMLAYLGWCI FPTSKLSYQA ETPAQNSHHP AARSPASAVI GGGGKGEPIS
     RPGVDPSSPP GAIFEENAAK DDRVFQLAVS DLSLNDDILQ SEKITYSIKV IEANNPFQAV
     QEACDLMTQG ILALVTSTGC ASANALQSLT DAMHIPHLFV QRNPGGSPRT ACHLNPSPDG
     EAYTLASRPP VRLNDVMLRL VTELRWQKFV MFYDSEYDIR GLQSFLDQAS RLGLDVSLQK
     VDKNISHVFT SLFTTMKTEE LNRYRDTLRR AILLLSPQGA HSFINEAVET NLASKDSHWV
     FVNEEISDPE ILDLVHSALG RMTVVRQIFP SAKDNQKCMR NNHRISSLLC DPQEGYLQML
     QISNLYLYDS VLMLANAFHR KLEDRKWHSM ASLNCIRKST KPWNGGRSML DTIKKGHITG
     LTGVMEFRED SSNPYVQFEI LGTTYSETFG KDMRKLATWD SEKGLNGSLQ ERPMGSRLQG
     LTLKVVTVLE EPFVMVAENI LGQPKRYKGF SIDVLDALAK ALGFKYEIYQ APDGRYGHQL
     HNTSWNGMIG ELISKRADLA ISAITITPER ESVVDFSKRY LDYSVGILIK KPEEKISIFS
     LFAPFDFAVW ACIAAAIPVV GVLIFVLNRI QAVRAQSAAQ PRPSASATLH SAIWIVYGAF
     VQQGGESSVN SMAMRIVMGS WWLFTLIVCS SYTANLAAFL TVSRMDNPIR TFQDLSKQVE
     MSYGTVRDSA VYEYFRAKGT NPLEQDSTFA ELWRTISKNG GADNCVSSPS EGIRKAKKGN
     YAFLWDVAVV EYAALTDDDC SVTVIANSVS SKGYGIALQH GSPYRDLFSQ RILELQDTGD
     LDVLKQKWWP HTGRCDLTSH TSAQADGKSL KLHSFAGVFC ILAIGLLLAC LVAALELWWN
     SNRCHQETPK EDKEVNLEQV HRRMNSLMDE DIAHKQISPA SIELSALEMG GLAPSQALEP
     TREYQNTQLS VSTFLPEQSS HGTSRTLSSG PSSNLPLPLS SSATMPSMQC KHRSPNGGLF
     RQSPVKTPIP MSFQPVPGGV LPEALDTSHG TSI
//
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